Theoretical analysis of propagation properties in a hollow-core Bragg fiber for bio-sensing applications has been demonstrated. Based on the Bragg fiber we propose a resonant sensor that operates on changes in refractive index of aqueous solution placed inside the hollow core. By using the transfer matrix method we analyzed the confinement loss of the TE_{01} mode in the hollow-core Bragg fiber. We have shown the influence of the fiber geometry on the changes in the confinement loss. Spectral sensitivity and resolution of the sensor are also presented.
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