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Practical Approach to Inguinal Hernia Treatment -Guidelines of the Association of Polish Surgeons

100%

Matyja A., Pasternak A., Solecki R., Szura M., Matyja M., śmietański M., Wallner G.

Polish Journal of Surgery

2015

vol. 86

issue 11

552-554

Primary Adenocarcinoma of the Appendix – A Case Report

84%

Pasternak A., Pach R., Szura M., Solecki R., Tomaszewski K. A., Szczepański W., Matyja A., Kulig J.

Polish Journal of Surgery

2015

vol. 86

issue 7

333-336

Primary adenocarcinoma of the vermiform appendix is a rare clinical condition. It usually presents as an acute abdominal process or as a mass in the right lower quadrant. The gross pathologic and microscopic characteristics of this disease are the same as for colon carcinoma and carry a serious prognosis. We report a case of a 64-year old male patient presenting symptoms of acute appendicitis. The patient underwent laparoscopic appendectomy that revealed a severely inflamed appendix. Histopathological examination has shown that it was a poorly differentiated, high grade adenocarcinoma invading the periappendicular fat. According to the histopathological findings, a right hemicolectomy was further advised and performed. Right hemicolectomy is the generally recommended method of treatment for invasive adenocarcinoma of the appendix

Interstitial Cajal-Like Cells and Bile Lithogenicity in the Pathogenesis of Gall-Stone Disease

84%

Pasternak A., Matyja A., Gil K., Gajda M., Tomaszewski K. A., Matyja M., Walocha J. A., Kulig J.

vol. 85

issue 6

311-316

Gall-stone disease constitutes a serious clinical problem and is the most frequent cause of elective cholecystectomies. There are many etiopatogenic factors however; lithogenic bile and its stasis due to gall-bladder hypomotility seem to be the most important. In recent years discovery of pacemaker function of Interstitial Cells of Cajal changed our understanding of smooth muscle physiology and helped to disclose many gastrointestinal motility disorders. The aim of the study was identification and quantification of interstitial Cajal-like cells (ICLCs) in gall-bladder muscle wall from patients with cholelithiasis and in gall-stone-free controls, as well as determination of the relationship between the number of ICLCs and Cholesterol Saturation Index (CSI) of bile in both analyzed groups. Material and methods. 20 patients operated for symptomatic cholelithiasis were enrolled into the study group. The control group consisted of 20 patients operated for pancreatic head tumors, with no pre- and intraoperative signs of gall-stones. Identification of ICLCs in the gall-bladder was performed by means of double immunofluorescence technique with anti c-Kit and anti-mast cell tryptase antibodies. Quantitative analysis was carried out under fluorescence microscopy conjoined with image analysis software. Bile samples were used for calculation of CSI. Results. ICLCs were detected within gall-bladder muscle wall. Number of ICLCs was statistically significantly lower in patients from the study group as compared to control. The study also revealed statistically significantly higher CSI in the study group. Conclusions. The quantity of ICLCs is diminished in the gall-bladder from patients with cholelithiasis and there is negative correlation between the number of ICLCs and CSI of bile. Regarding the role of ICCs in regulation of GI tract motility, it appears that reduction in their number may be important etiopatogenic factor of cholelithiasis.

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3 Polish Journal of Surgery

1 2015

1 2014

1 2013

3 Matyja A.

3 Pasternak A.

2 Kulig J.

2 Matyja M.

2 Solecki R.

2 Szura M.

2 Tomaszewski K. A.

1 Gajda M.

1 Gil K.

1 Pach R.

1 Szczepański W.

1 Wallner G.

1 Walocha J. A.

1 śmietański M.

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Practical Approach to Inguinal Hernia Treatment -Guidelines of the Association of Polish Surgeons

Primary Adenocarcinoma of the Appendix – A Case Report

Interstitial Cajal-Like Cells and Bile Lithogenicity in the Pathogenesis of Gall-Stone Disease