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Analytical performance of a fast multi-element method for titanium and trace elements determination in cosmetics and pharmaceuticals by ICP-AES

100%

Zachariadis G., Sahanidou E.

Open Chemistry

2011

vol. 9

issue 2

213-217

A multi-element analytical method based on inductively coupled plasma atomic emission spectrometry (ICP-AES) was developed for trace elements in pharmaceutical tablets and cosmetics. Titanium was also included in the analytes since it is widely used in pharmaceuticals. Critical ICP conditions, like RF incident power, argon gas flow rate and nebulizer sample uptake flow rate were optimized. The most sensitive spectral line of each analyte was selected as optimum for further study. Detection limits in the low µg g−1 range were obtained. Prior to chemical analysis, the samples were decomposed by acid digestion, using various mixtures of HCl, HNO3 and HF. Yttrium was used as a suitable internal standard in order to correct for possible matrix effects. The method was applied to the analysis of six different pharmaceutical products (anti-biotic, anti-inflammatory, anti-hypertensive) in the form of tablets with film coating and also three cosmetic products like hair and face masks.

Ion chromatographic method for the determination of cations of group IA and IIA in water samples, pharmaceuticals and energy drinks by non-suppressed conductometric detection

81%

Zachariadis G., Lyratzi A., Stratis J.

Open Chemistry

2011

vol. 9

issue 5

941-947

An efficient ion chromatographic (IC) method was developed for the simultaneous quantitative determination of Li+, Na+, NH4+, K+, Cs+, Ca2+, Mg2+, Sr2+, Ba2+ and Be2+ in energy drinks, pharmaceutical and drinking water samples by non-suppressed conductometric detection. The separation of ten cations including ammonium was achieved using a cation-exchange column and low conductivity mobile phase. The mobile phase consisted of tartaric acid, dipicolinic acid and boric acid. The separation of the cations was completed in less than 18 min, with a flow rate of 1.2 mL min−1. The separation was not affected by the existence of cations Co2+, Cr3+, Cd2+, Cu2+, Bi3+, Ag+, Fe3+ and Zn2+ in concentrations up to 20 mg L−1. Using an injection volume of 20 μL the obtained detection limits were 0.003 mg L−1, 0.02 mg L−1, 0.01 mg L−1, 0.01 mg L−1, 0.10 mg L−1, 0.01 mg L−1, 0.02 mg L−1, 0.02 mg L−1, 0.003 mg L−1 and 0.1 mg L−1, for Li+, Na+, NH4+, K+, Cs+, Ca2+, Mg2+, Sr2+, Be2+ and Ba2+ respectively. The intra-day repeatability (RSD%, n=5) ranged from 1.1% to 4.8%, and the inter-day (n=5) between 1.8% and 5.4% respectively. The method was applied to the analysis of various bottled and tap water, pharmaceutical preparations and energy drinks commercially available. [...]

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2 Open Chemistry

2 2011

2 Zachariadis G.

1 Lyratzi A.

1 Sahanidou E.

1 Stratis J.

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Analytical performance of a fast multi-element method for titanium and trace elements determination in cosmetics and pharmaceuticals by ICP-AES

Ion chromatographic method for the determination of cations of group IA and IIA in water samples, pharmaceuticals and energy drinks by non-suppressed conductometric detection