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1

Interleukin 18

100%
Fol M., Goscicka T.
Postępy Higieny i Medycyny Doświadczalnej
|
2003
|
vol. 57
|
issue 6
685-699
EN
The paper describes the properties of interleukin-18 (IL-18), the cytokine originally designated as interferon-gamma inducing factor (IGIF): its production, structure and receptor (IL-18R) transmitting a signal to the cell. Moreover, it presents recent data on its biological activity.
2

Interleukin-12 (IL-12) and its receptor

100%
Szeliga J., Goscicka T.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
|
vol. 56
|
issue 2
185-199
EN
This article reviews of recent data on the structure of IL-12 and the function of its receptor (IL-12R). It presents a new opinion on the role of its subunits in the cytokine activity and on the signal transmission via IL-12R in the process of cell activation by IL-12
3

Influence of dendritic cells on the in vitro allogeneic cytotoxic reaction of lymphoid cells derived from normal or listeria innocua-infected BALB/c mice

71%
Goscicka T., Walencka M., Fol M., Krupa A., Szeliga J.
Archivum Immunologiae et Therapiae Experimentalis
|
2001
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vol. 49
|
issue 6
447-452
EN
The role of lymphoid dendritic cells (DCs) in the development of an allogeneic cytotoxic reaction in vitro was examined. The T+B and T cell subsets originating from the spleens or lymph nodes of normal and Listeria innocua-infected BALB/c mice were used as the effector cells. Their cytotoxicity to 51Cr-labeled C3H fibroblasts was determined after removal of DCs and replacing them again. Moreover, the influence of exogenous mrIL-12 on the potency of DCs in the allogeneic reaction developed in vitro was checked. It was found that the DC-deprived T+B or T subsets of splenocytes, regardless of their origin, exhibited 27-38% lower cytotoxicity than those accompanied by natural DCs. The cytotoxicity of these subsets from normal lymph nodes decreased by 22%, while the activity of bacteria-primed cells dropped by 38%. Replenishing effector cells with isolated DCs restored their cytotoxicity. Pulsation of normal DCs with IL-12 had no effect on the recovery of normal cell cytotoxicity. However, the IL-12-pulsed DCs were able to intensify the cytotoxicity of T+B subsets derived from the spleens or lymph nodes of L. innocua-infected mice. The results suggest that the alloantigen presentation by DCs to cytotoxic lymphocytes also takes place in the reaction developed in vitro, regardless of effector cell origin.
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