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Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I.

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Zubrzak P., Kociołek K., Smoluch M., Silberring J., Kowalski M. L., Szkudlińska B., Zabrocki J.

2001

vol. 48

issue 4

1151-1154

Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3, Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile-Ψ[CN4]-Ala3, Pro3-Ψ[CN4]-Ala4 and Val6-Ψ[CN4]-Alawere synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte proliferation test (LPT).

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1 Acta Biochimica Polonica

1 2001

1 Kociołek K.

1 Kowalski M. L.

1 Silberring J.

1 Smoluch M.

1 Szkudlińska B.

1 Zabrocki J.

1 Zubrzak P.

Search results

Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I.