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Regional differences in the vulnerability of substantia nigra dopaminergic neurons in weaver mice

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Marti J., Santa-Cruz M. C., Molina V., Serra R., Bayer S. A., Ghetti B., Hervas J. P.

Acta Neurobiologiae Experimentalis

2009

vol. 69

issue 2

198-206

Vulnerability of midbrain dopaminergic (DA) neurons in the weaver mouse was studied at postnatal (P) days 8 and 90, in chosen coronal levels throughout the anteroposterior (AP) extent of the substantia nigra pars compacta (SNc). Wild-type (+/+) and homozygous weaver (wv/wv) mice used were the offspring of pregnant dams injected in several cases with tritiated thymidine on embryonic days 11-15. DA neurons were identified for their tyrosine hydroxylase immunoreactivity. Data reveal that at P8, the frequency of both +/+ and wv/wv late-generated DA cells increases from rostral to caudal SNc. No apparent DA-cell loss was observed at P8 in the mutant genotype, irrespective of the AP level considered. However, throughout the AP, there was a significant reduction in the number of these neurons at any level in 90-day-old weavers. Comparison of P8 and P90 +/+ SNc suggests that cell death is not a major aspect in the developmental regulation of normal DA neurons, although numerical cell depletion in the postnatal development of weaver SNc probably results from the amplification of a basal cell-death process, which affected all the coronal levels studied.

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1 Acta Neurobiologiae Experimentalis

1 2009

1 Bayer S. A.

1 Ghetti B.

1 Hervas J. P.

1 Marti J.

1 Molina V.

1 Santa-Cruz M. C.

1 Serra R.

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Regional differences in the vulnerability of substantia nigra dopaminergic neurons in weaver mice