Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 3

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Content available remote

New approaches in layer by layer synthesis of collagen/hydroxyapatite composite materials

100%
Ilie A., Andronescu E., Ficai D., Voicu G., Ficai M., Maganu M., Ficai A.
Open Chemistry
|
2011
|
vol. 9
|
issue 2
283-289
EN
The aim of this work was to increase our understanding of collagen (COLL)/ hydroxyapatite (HA) composite materials; more specifically, we focused on the study of the influence of the precursorconcentrations over the final content of deposited HA. We found that the increase of the precursor concentrations led to better mineralization (on the basis of the content of deposited mineral phase). Regardless of the precursor concentrations, the content of the deposited amount was found to increase with the increase of the number of deposited layers. Quantification of the mineral phase amount was achieved by gravimetric determination. Based on the determined deposition equation the number of layers can be easily determined in order to obtain composite materials with desired content of mineral phase.
2
Content available remote

Synthesis, characterization and bioevaluation of irinotecan-collagen hybrid materials for biomedical applications as drug delivery systems in tumoral treatments

100%
Voicu G., Geanaliu R., Ghiţulică C., Ficai A., Grumezescu A., Bleotu C.
Open Chemistry
|
2013
|
vol. 11
|
issue 12
2134-2143
EN
The purpose of the present study is the preparation and characterization of collagen/antitumor drug hybrids as drug delivery systems. Materials used for obtaining collagen-based drug delivery systems were collagen type I (Coll) as matrix and irinotecan (I) as hydrophilic active substances. After incorporation of I into Coll in differing ratios, the obtained hybrid materials (Coll/I) could be used according to our results as potential drug delivery systems in medicine for the topical (local) treatment of cancerous tissues or bone. The released amount of I varies with amount of Coll from hybrid materials: the higher, the slower the release amount of irinotecan transferred is in the first 6 hours. The in vitro citotoxicity demonstrates an antitumoral activity of the obtained hybrid materials and their potential use for biomedical applications as drug delivery systems in tumoral treatments. [...]
3
Content available remote

Mimicking the morphology of long bone

100%
Ficai A., Andronescu E., Ficai D., Sonmez M., Albu M., Voicu G.
Open Chemistry
|
2012
|
vol. 10
|
issue 6
1949-1953
EN
The aim of this work was to mimic the stratified structure of the median region of long bones. Starting from this desideratum, more COLL/HA composite materials with different morphology were synthesized and characterized, each of these materials mimicking one layer of long bone (endo- and periosteum, compact and cancellous bony tissue). Stratified bone grafts were obtained by assembling these layers; the obtained grafts were similar to the median region of long bones. Even though, natural bones have a more complex microstructure, this is a pioneering work since for the first time a stratified COLL/HA composite material similar to bone was produced. [...]
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.