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1
Content available remote

Survival of patients with head and neck squamous cell carcinoma in association with human papillomavirus and p53 polymorphism

100%
Gudleviciene Z., Smailyte G.
Open Medicine
|
2012
|
vol. 7
|
issue 3
349-353
2
Content available remote

Demographic differences in cervical cancer survival in Lithuania

81%
Ulinskas K., Aleknaviciene B., Smailyte G.
Open Medicine
|
2013
|
vol. 8
|
issue 1
16-21
3
Content available remote

Combined treatment and survival of medullary thyroid carcinoma patients

81%
Baranauskas Z., Valuckas K., Smailyte G.
Open Medicine
|
2010
|
vol. 5
|
issue 4
426-430
EN
The aim of this study is to analyze the impact of combined treatment (thyroidectomy and radiotherapy and radioactive iodine treatment) on patients’ long-term survival with medullary thyroid carcinoma. This is a retrospective study of 59 patients treated from 1977 to 2006 for medullary carcinoma at the Institute of Oncology in Vilnius, Lithuania. Survival was estimated by the Kaplan-Meier method. Univariate and multivariate Cox proportional hazard models were used to explore the association of prognostic factors with long-term survival. The survival of MTC patients was 88.0% (95% CI 68.0–88.9), 67.9% (95% CI 52.3–79.4) and 60.5% (95% CI 43.2–74.0), respectively, 5, 10 and 15 years after diagnosis. In survival analysis, only the type of surgery and lymph node involvement were found to be significant prognostic factors. The results of this study suggest that treatment with radioiodine and external beam radiotherapy do not improve significantly the long-term survival of surgically treated MTC patients.
4
Content available remote

Comparison of prostate cancer patient’s survival in Belarus and Lithuania

71%
Smailyte G., Averkin Y., Veyalkin I., Krasny S., Ulinskas K.
Open Medicine
|
2011
|
vol. 6
|
issue 5
545-549
5
Content available remote

Rare types of breast carcinoma

71%
Gudaviciene D., Steponaviciene L., Meskauskas R., Smailyte G., Aleknavicius E.
Open Medicine
|
2014
|
vol. 10
|
issue 1
EN
Breast cancer (BC) is a heterogeneous disease that encompasses several distinct entities with remarkably different characteristics. Histological type is one of important BC characteristics. Histological type is associated with differences in epidemiology, diagnostic issues, clinical course, prognosis. When we talk about BC, ductal and lobular carcinoma is usually what we have in mind. However, the other types that comprise less than 10% of BC are also very important. The rarity of many of these neoplasms does not allow large or randomized studies to define the optimal treatment. Many of the descriptions are from case reports and small series. The aim of this retrospective study was to analyze the data on rare breast cancers, to describe their main characteristics, and to calculate survival rates. We believe that the experience of our institution will contribute to the available data about these rare breast cancers and help in better understanding of this subgroup.
6
Content available remote

Endometrial cancer and microsatellite instability status

61%
Kanopiene D., Vidugiriene J., Povilas Valuckas K., Smailyte G., Uleckiene S., Bacher J.
Open Medicine
|
2014
|
vol. 10
|
issue 1
EN
Microsatellite instability (MSI) is an important factor in the development of various cancers as an identifier of a defective DNA mismatch repair system. The objective of our study was to define the association between microsatellite instability status and traditional clinicopathologic characteristics of endometrioid type adenocarcinoma. Material and methods: MSI status of endometrial cancer was examined by employing the Promega MSI Analysis System. This system uses 5 mononucleotide markers to identify MSI in tumour and normal tissue DNA (BAT-25, BAT-26, NR-21, NR-24, and MONO-27), and 2 pentanucleotide markers (Penta C and Penta D) for specimen identification. In this study, we investigated MSI status in 109 endometrial carcinomas. Results and conclusions: One hundred (92%) of 109 endometrial cancers showed endometrioid type histology and only 9 (8%) non-endometrioid type. MSI-high was found in 17% (17/100) of endometrioid type adenocarcinomas, in 0% (0/9) of non-endometrioid carcinomas. Selected clinicopathologic parameters for endometrioid type adenocarcinomas were compared to the MSI status which was separated into two groups – MSI-high and MSI stable. The results showed that MSI-high status was related to clinicopathologic parameters such as deep myometrial invasion and higher histologic grade in endometrioid type adenocarcinomas.
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