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Comparison between the Polish population and European populations on the basis of mitochondrial morphs and haplogroups.

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Piechota J., Tońska K., Nowak M., Kabzińska D., Lorenc A., Bartnik E.

vol. 51

issue 4

883-895

Polymorphisms in mitochondrial DNA (mtDNA) were analyzed in 152 samples from the Polish population using restriction enzymes AvaI, BamHI, HaeII, HpaI and PstI. Additionally, each sample was classified into the appropriate haplogroup. When required, appropriate fragments were sequenced to establish the exact polymorphic sites. We found one new morph for PstI and six new morphs for AvaII. Some detected morphs have previously been described as population specific morphs in different regions of the world. All polymorphisms were classified into 31 different haplotypes. 21 of them were detected in single individuals. The Polish population was compared with other populations from different regions. Moreover, we have obtained evidence for mutation hot spots in the mtDNA coding region. Our results indicate that AvaII morph and haplogroup composition of the Polish population is similar to other European populations and has a distribution typical for this part of the world. However, statistically significant differences in haplogroup composition were found between the Polish population and Italian and Finnish populations.

Mitochondrial DNA in pediatric leukemia patients

100%

Kodroń A., Ghanim M., Krawczyk K., Stelmaszczyk-Emmel A., Tońska K., Demkow U., Bartnik E.

2017

vol. 64

issue 1

183-187

Numerous studies of mitochondrial DNA (mtDNA) in cancer have shown differences between mtDNA sequences in tumor and normal tissue and at various stages of cancer treatment in the same patient. However, there is little data on acute lymphoblastic leukemia (ALL), the most common type of leukemia in children. In this study we compared mitochondrial sequence variation in the D-loop region and in 5 genes of mtDNA in bone marrow samples of 6 pediatric patients with ALL at various stages of therapy. We found several common polymorphisms and one variant at position 3688 whose level varied during leukemia treatment. Our results suggest that mitochondrial DNA mutations, whose levels change during patient treatment, could be potential biomarkers for monitoring treatment efficacy and disease progression.

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2 Acta Biochimica Polonica

1 2017

1 2004

2 Bartnik E.

2 Tońska K.

1 Demkow U.

1 Ghanim M.

1 Kabzińska D.

1 Kodroń A.

1 Krawczyk K.

1 Lorenc A.

1 Nowak M.

1 Piechota J.

1 Stelmaszczyk-Emmel A.

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Comparison between the Polish population and European populations on the basis of mitochondrial morphs and haplogroups.

Mitochondrial DNA in pediatric leukemia patients