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Motor deficiency in Parkinson's disease

100%

Blaszczyk J.

vol. 58

issue 1

79-93

The basal ganglia comprise a group of gray matter structures beneath the cerebral cortex, that surrounds the thalamus and hypothalamus. The basal ganglia play an important role in controlling movement. The motor circuits within the striato-pallidal complex are thought to facilitate desired movement and inhibit unwanted movement through their influence, via the thalamus, mainly on cortical precentral motor regions. Localized damage to parts of the basal ganglia occurs in certain diseases such as Parkinson's disease. Parkinsonism is a common neurological disorder that affects about one person in every 1,000 of the general population and about 2% in the elderly. The diagnosis of Parkinson's disease is based on the presence of two or more of the major symptoms: tremor, rigidity, postural instability, and bradykinesia. The pathological process behind the motor disabilities of Parkinsonism is a progressive degeneration of dopaminergic neurons of the substantia nigra, that results in dopamine depletion in the striatum. Brain dopamine deficiency is sufficient to explain all of the major symptoms of Parkinson's disease.

Sex and strain differences of acoustic startle reaction development in adolescent albino Wistar and hooded rats

63%

Blaszczyk J., Tajchert K.

Acta Neurobiologiae Experimentalis

1996

vol. 56

issue 4

919-925

Acoustic startle responses (ASR) were studied in 12 young Wistar albino and in 15 hooded rats of both genders. The six week old animals were first exposed to a 6.9 kHz tone pair of 2 ms pulses of 120 db intensity with the inter-stimulus interval (ISI) between 2 and 11 ms. ASR amplitudes and latencies as a function of the ISI, animal strain and gender were recorded and analyzed for ten consecutive weeks. No differences in the ASR amplitude between Wistar and hooded rats were found. ASR amplitude increased during the experimental period and followed body weight increase. Signiflcant differences were also observed between male and female rats in their startle responses to acoustic stimuli. Generally, male subjects responded with a greater ASR amplitude than females, and the changes may be attributed to the difference in neuromuscular development between genders. This experiment sets a background for further developmental studies

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2 Acta Neurobiologiae Experimentalis

1 1998

1 1996

2 Blaszczyk J.

1 Tajchert K.

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Motor deficiency in Parkinson's disease

Sex and strain differences of acoustic startle reaction development in adolescent albino Wistar and hooded rats