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Alzheimer's amyloid-beta (A beta) is an essential synaptic protein, not neurotoxic junk

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Koudinov A. R., Berezov T. T.

Acta Neurobiologiae Experimentalis

2004

vol. 64

issue 1

71-91

Despite a decade long universal publication in favor of the view on amyloid-beta (A beta ) as Alzheimer's disease culprit (solely neurotoxic for neurons and brain tissue), current scientific evidence leaves little doubt that A? serves an essential role at synapse and in synaptic structure-functional plasticity that underlie learning and memory. Therefore, the change of A beta biology in Alzheimer's disease (as well as in a number of other human pathologies, including cardiovascular disease, neuromuscular junction disorders, NPC and Down's syndrome) may represent a physiological mechanism to compensate for impaired brain structure or function. In our own recent study A beta1-40 rescued long term potentiation (LTP, a major model for activity-dependent CNS plasticity), while cholesterol synthesis inhibition abolished the restorative action of the A beta peptide. This study confirms that A beta protein is a functional player in synaptic structure-functional plasticity and in cholesterol neurochemical pathways. The article also calls for a need to critically re-evaluate a universal belief that transgenic mice with a transgene for amyloid-beta protein precursor (A betaPP) are a true model for Alzheimer's type neurodegeneration.

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1 Acta Neurobiologiae Experimentalis

1 2004

1 Berezov T. T.

1 Koudinov A. R.

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Alzheimer's amyloid-beta (A beta) is an essential synaptic protein, not neurotoxic junk