Search results

1

Skin-induced tolerance and its reversal by Toll-like receptor ligands

100%

Szczepanik M.

Archivum Immunologiae et Therapiae Experimentalis

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2007

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vol. 55

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issue 3

161-172

EN

In 1970, Gershon was the first to propose that T cells, in addition to their helper activity, can also play a role as regulatory cells capable of suppressing immune responses. However, the initial strong interest in T cell-mediated suppression was followed by a period of doubt and skepticism. Since the late 1990s the 'S' word started to be used in immunology again and interest in T suppressor cells has grown, ushering in a new renaissance for the field. In this article the author presents the current knowledge about a new subject called 'skin-induced tolerance'. Suppression is induced via epicutaneous immunization and is described in both Th1- and Tc1-mediated contact sensitivity reactions. The subject of skin-induced tolerance is also considered in the regulation of experimental models of autoimmune diseases such as allergic autoimmune encephalomyelitis and collagen-induced arthritis and finally in an animal model of graft rejection. The last part of this presentation will introduce the very fresh subject of ?contrasuppression', or the reversal of skin-induced suppression.

2

Swarm optimization of stiffeners locations in 2-D structures

64%

Szczepanik M., Burczyński T.

Bulletin of the Polish Academy of Sciences: Technical Sciences

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2012

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issue 2

3

The influence of non-specific anti-pruritus treatment with cyclosporine A on transepidermal water loss (TEWL) in natural atopic dermatitis in dogs

45%

Zając M., Szczepanik M., Wilkołek P., Adamek Ł., Pomorski Z.

Polish Journal of Veterinary Sciences

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2015

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issue 2

4

Epidemiological Study of Canine Mast Cell Tumours According to the Histological Malignancy Grade

39%

Śmiech A., Jasik A., Ślaska B., Łopuszyński W., Szczepanik M., Wilkołek P.

Polish Journal of Veterinary Sciences

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2017

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issue 3

5

The evaluation of selected parameters of cellular nonspecific immunity in normal and allergic horses

39%

Wilkołek P., Gołyński M., Szczepanik M., Adamek Ł., Pomorska A., Maj-Martyniuk M., Sitkowski W.

Polish Journal of Veterinary Sciences

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2011

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issue 2

6

TCR alpha beta+ CD8+ and TCR gamma delta lymphocytes inhibit the capability of peritoneal macrophages to induce contact hypersensitivity

39%

Majewska M., Zajac K., Zemelka M., Sura P., Gryglewski A., Szczepanik M.

Folia Biologica

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2009

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vol. 57

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issue 1-2

23-27

EN

Macrophages (Mf) play an important role in induction and regulation of the immune response. It was shown previously that subcutaneous injection of hapten conjugated macrophages (TNP-Mf) induces the contact hypersensitivity (CHS) response, whereas intravenous (i.v.) or intraperitioneal administration of TNP-Mf results in unresponsiveness as a result of induced T suppressor (Ts) cells. The aim of this study was to determine if different T cell populations influence macrophages to become inducers of immunological suppression. Our findings show that indeed i.v. injection of TNP labeled macrophages isolated from control mice into syngenic recipients induces unresponsiveness. However, i.v. administration of TNP substituted macrophages isolated from TCR'-/-, TCR*-/- and $2m-/- mice induces strong CHS similar to that observed after skin painting with TNP-Cl.Moreover, it was shown that TNP conjugated macrophages isolated from CD1d-/- mice were still able to promote immunosuppression when injected intravenously. This suggests that TCR'$+ CD8+ and TCR(*+ lymphocytes stimulate macrophages to induce immunosuppression instead of a strong CHS reaction, whereas CD1d dependent NKT cells are not involved in negative regulation of macrophage function.

7

Serum tT4, fT4 and TSH concentrations in German Shepherd dogs depending on age and type of work

37%

Taszkun I., Milczak A., Kalisz G., Wilkołek P., Zwolska J., Szczepanik M., Taszkun I., Milczak A., Kalisz G., Wilkołek P., Zwolska J., Szczepanik M.

Polish Journal of Veterinary Sciences

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2021

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vol. 24

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issue 1

8

Comparison of serum concentrations of environmental allergen-specific IgE in atopic and healthy (nonatopic) horses

33%

Gołyński M., Wilkołek P., Sitkowski W., Szczepanik M., Adamek Ł., Pluta M., Taszkun I., Malinowska A.

Polish Journal of Veterinary Sciences

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2017

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issue 4

Refine search results

Skin-induced tolerance and its reversal by Toll-like receptor ligands

Swarm optimization of stiffeners locations in 2-D structures

The influence of non-specific anti-pruritus treatment with cyclosporine A on transepidermal water loss (TEWL) in natural atopic dermatitis in dogs

Epidemiological Study of Canine Mast Cell Tumours According to the Histological Malignancy Grade

The evaluation of selected parameters of cellular nonspecific immunity in normal and allergic horses

TCR alpha beta+ CD8+ and TCR gamma delta lymphocytes inhibit the capability of peritoneal macrophages to induce contact hypersensitivity

Serum tT4, fT4 and TSH concentrations in German Shepherd dogs depending on age and type of work

Comparison of serum concentrations of environmental allergen-specific IgE in atopic and healthy (nonatopic) horses