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Possibilities of nanodiamonds application – biological and medical aspects

100%

Solarska-Ściuk K., Kleszczyńska H.

Acta Poloniae Pharmaceutica - Drug Research

2019

vol. 76

issue 5

779-796

This topical review briefly discusses selected highlights of research on diamond nanoparticles obtained by different methods and their potential applications in biology and medicine. In recent years nanotechnology has aroused interest of large number of scientists who endeavor to obtain nanoparticles (which differ in size and structure of surface) using different methods, in order to determine their physical, chemical and biological properties that are in relation to the methods used in the process of their production. The knowledge developed in this way will be beneficial in an attempt to use nanoparticles more reasonably in various branches of science. The distinguishing features of carbon nanoparticles are their biocompatibility, photostability and easily chemically modified surface that result in high usefulness for intarcellular studies. What is more, low toxicity of nanoparticles with many cell lines is at the center of scientific interest. This, in turn, leads to a large number of biomedical applications. The property that nanodiamonds are able to penetrate into cells through endocytosis, allows to deliver the drug connected with nanoparticles into cancer cells. These features of nanoparticles have given many promising leads in nanooncology, in particular in drug delivery, diagnosis, imaging and therapy. This paper presents a summary of different classes of nanodiamond particles, the ways of their uptake into cells, an overview of the possible application of nanoparticles as nanocarriers and as a clinical theranostic platform, as well as advantages and disadvantages of using nanodiamonds in biomedicine.

ALLIUM URSINUM L. LEAVES COMPONENTS MODIFIED THE PHYSICO-CHEMICAL PROPERTIES OF RED BLOOD CELLS PROTECTING THEM FROM THE EFFECTS OF OXIDATIVE STRESS

81%

Cyboran-Mikołajczyk S. M., Kleszczyńska H., Oszmiański J., Pasławski R.

Acta Poloniae Pharmaceutica - Drug Research

2019

vol. 76

issue 3

483-491

The aim of the study is to determine the antioxidant activity and influence of Allium ursinum L. leaf extract on physicochemical and electrical properties of erythrocytes in order to help clarify its capacity to alleviate oxidative stress. The phenolic compounds were isolated from the leaves of bear garlic. The composition of the extract is well documented and was earlier analyzed quantitatively and qualitatively by UPLC methods. The impact of the extract constituents on the erythrocyte membrane properties was determined on the basis of its osmotic fragility, fluidity, organization of the hydrophilic area and transmembrane potential with spectrophotometric and fluorimetric methods. Furthermore, the effect of the extract on the level of membrane lipid oxidation and also on the extent of hemolysis of erythrocytes subjected to oxidation induced by AAPH compound was determined. The study showed that the extract at 40 µg/mL lowers the level of erythrocyte hemolysis caused by 76.8% oxidation. In addition, the extract protects lipid membranes against hemolysis better than ascorbic acid. The extract, in examined range of concentrations, did not induce hemolysis of erythrocytes, caused small decrease in their electric potential and osmotic fragility, and increased disorder of the polar heads of membrane lipids. The high antioxidant efficiency and determined effects of the interaction of bear garlic leaf extract with the erythrocyte membrane suggest that its constituents may not only protect cells against free radicals but also mitigate the effects of oxidative stress.

Influence of amphiphilic compounds on membranes.

61%

Przestalski S., Sarapuk J., Kleszczyńska H., Gabrielska J., Hładyszowski J., Trela Z., Kuczera J.

2000

vol. 47

issue 3

627-638

On the basis of Gortel & Grendel (J. Exp. Med., 1925, 41, 439-494) discovery, the importance of the lipid bilayer as an integral and indispensible component of the cell membrane is discussed. In particular, attention focuses on the interaction between membranes and amphiphilic substances. The effect on membranes of quaternary ammonium salts, both in the form of pesticides and oxidants as well as organic compounds of tin and lead are discussed in greater detail.

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2 Acta Poloniae Pharmaceutica - Drug Research

1 Acta Biochimica Polonica

2 2019

1 2000

3 Kleszczyńska H.

1 Cyboran-Mikołajczyk S. M.

1 Gabrielska J.

1 Hładyszowski J.

1 Kuczera J.

1 Oszmiański J.

1 Pasławski R.

1 Przestalski S.

1 Sarapuk J.

1 Solarska-Ściuk K.

1 Trela Z.

Search results

Possibilities of nanodiamonds application – biological and medical aspects

ALLIUM URSINUM L. LEAVES COMPONENTS MODIFIED THE PHYSICO-CHEMICAL PROPERTIES OF RED BLOOD CELLS PROTECTING THEM FROM THE EFFECTS OF OXIDATIVE STRESS

Influence of amphiphilic compounds on membranes.