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ANALYSIS OF IRON CONTENT IN FOOD SUPPLEMENTS IN RELATION TO THE SAFETY OF THEIR USE

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Surowiecka J. M., Olczyk P., Ivanova D., Kiselova-Kaneva: Y., Komosińska-Vassev K.
Acta Poloniae Pharmaceutica - Drug Research
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2020
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vol. 77
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issue 2
229-239
EN
Objective of the study was to test dietary supplements available on the European market with regard to their iron content. Twenty-nine vitamin and mineral supplements were investigated, with additional assessment of their mass homogeneity. Iron was determined by means of the AAS1 method following microwave mineralization of particular samples. Findings were compared to iron contents declared by producers. Tested supplements were analysed with regard to the ratio between the amount of iron supplied to the body and the RDA2 for adults and pregnant women, as well as in view of the number of preparation pieces required to be taken in in order to ensure the RDA in the groups included in the research. All preparations were characterised by high mass homogeneity. The iron content determined in the supplements was different from the values indicated by the producers on the packages. Four supplements did not meet the European requirements concerning acceptable limits of nutrient tolerance stated on the labels. Tolerance for iron value in food supplements indicated by producers on packages varied from RDAs for the studied groups. The dosage recommended by the producer was mostly different from the dosage necessary to meet the requirements for iron RDA in the studied groups.
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Cytostatic therapy and blood antioxidants/prooxidants balance in acute myeloblastic leukemia patients

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Gerova D., Gerov V., Yankova T., Gercheva L., Ivanova D.
Open Medicine
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2006
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vol. 1
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issue 1
35-45
EN
To analyze the effects of conventional polychemotherapy of acute myeloblastic leukemia (AML) patients on the prooxidants/antioxidants balance in plasma total antioxidant status (TAS) and a single plasma antioxidant - uric acid (UA) were measured. Lipid peroxidation was assessed by malonedialdehyde (MDA) content. Total serum iron was monitored as a potential source of nontransferrin-bound iron with a role in initiation of oxidative burst. A group of patients in the acute phase of AML (group A) and a group of patients in complete remission of AML (group B) were studied. A strong correlation between UA values and TAS (r = 0.8 for group A, r = 0.9 for group B) was revealed in the course of the treatment. Strong negative correlation (r = −0.9) between TAS and MDA was shown for both groups. Total iron significantly increased in the course of chemotherapy. We have established that polychemotherapy leads to the consumption of antioxidants and increased lipid peroxidation in AML patients. An appropriate supplementation with antioxidants at the end of the polychemotherapy treatment could be considered.
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