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An attempt at comparing external changes taking place during maturation of male mice with the development of the process of spermatogenesis

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Wirth-Dzieciolowska E., Sysa P. S., Ponimasz A.

Evaluation of the degree of sexual maturation was performed in male mice of two selected lines differing in respect of body weight. Four developmental stages were distinguished: (1) loosening of the skin between the urinary papilla and the anus, (2) projection of the scrotum, (3) descent of the testes to the scrotum, (4) demonstration of sexual drive. Histological examination of the testes revealed that at the first developmental stage the animals had clearly immature gonads. In a few, not numerous, seminiferous tubules spermatogenesis had reached the phase of primary spermatocytes. At the second stage of development the male gonads reached the phase of secondary spermatocytes and sporadically of early spermatids. At the third stage of the animals development, the spermatogenesis observed in numerous cross-sections of the seminiferous tubules reached the spermatid phase and in males at the fourth stage some sperm cells appeared in the lumen of the tubules. A greater diameter of the sperminiferous tubles was demonstrated in the heavy line males than in the light line animals. In males of the heavy line the diameter of the Leydig cells increased between the third and fourth stage. The investigation results suggest that the accepted criteria of determination of sexual maturation stages correspond to various phases of changes taking place in the process of spermatogenesis.

Selection for body weight induces differences in exploratory behavior and learning in mice

100%

Wirth-Dzieciolowska E., Lipska A., Wesierska M.

Acta Neurobiologiae Experimentalis

2005

vol. 65

issue 3

243-253

Mice that were selected for over 108 generations for body weight at the postnatal (PN) day 21 were examined in the open field (OF) test and in the Lashley maze (LM) for their exploratory behavior and spatial learning. Light (L), heavy (C) and control (K) lines of mice in three age groups: PN-21, PN-56 and PN-90, were tested once in the OF and three times in the LM. During the session in the OF the L mice displayed a steady increase of behavioral activity (sum of locomotion and rearing, climbing, sniffing, and grooming acts), whereas mice C and K habituated in the last stage. During entire session in the OF activity of the L mice was lower than that of the C and K mice. The L mice displayed high defecation/urination scores. In the learning task the L mice performed worse than the C and K mice. In conclusion, behavior of the L line was different from that of the two other lines: they showed higher anxiety and poorer spatial learning.

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1 Acta Neurobiologiae Experimentalis

1 Folia Biologica

1 2005

1 1997

2 Wirth-Dzieciolowska E.

1 Lipska A.

1 Ponimasz A.

1 Sysa P. S.

1 Wesierska M.

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An attempt at comparing external changes taking place during maturation of male mice with the development of the process of spermatogenesis

Selection for body weight induces differences in exploratory behavior and learning in mice