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RHEOLOGICAL ASPECTS OF THE FLOW OF THERMOSENSITIVE CHITOSAN SYSTEMS DURING INJECTION APPLICATION

100%
Rył A., Owczarz P.
Progress on Chemistry and Application of Chitin and its Derivatives
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2020
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vol. 25
201 - 209
EN
The aim of this paper was to conduct preliminary instrumental tests to determine the possibility of injection applications for thermosensitive chitosan systems, including injection needles and application conditions. Among the many biomedical and pharmaceutical applications of chitosan, the minimally invasive thermosensitive scaffolds that form in vivo are an interesting solution. Despite many studies on colloidal chitosan systems undergoing sol-gel phase transition, almost no studies have examined their injectability. It has been stated that the use of acetic acid as a solvent reduces the forces needed for injection. Moreover, the key impact of injection temperature was determined. Storing the medium at room temperature before the injectability test led to a decrease in the value of forces needed for injection. The obtained results are discussed based on the change of the rheological properties of the chitosan hydrogels.
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THE INFLUENCE OF THE ADDITION OF COLLAGEN ON THE RHEOLOGICAL PROPERTIES OF CHITOSAN CHLORIDE SOLUTIONS

81%
Owczarz P., Rył A., Modrzejewska Z., Dziubiński M.
Progress on Chemistry and Application of Chitin and its Derivatives
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2017
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vol. 22
176 - 189
EN
Colloidal solutions of chitosan of crab origin with the addition of collagen obtained from cowhide were studied. Were presents the influence of collagen concentration and the method of preparing the sample on the obtained mechanical properties of the solutions and the observed phase transition temperature. Rheological measurements were performed to determine the viscoelastic properties and phase transition temperatures of these solutions. The study was conducted in the temperature range of 5–60°C with the use of classical techniques of rotational rheometry in the cone-plate measurement system. A significant influence of a collagen addition to chitosan chloride solutions on the viscoelastic properties of the systems was observed. The addition of collagen in all the cases increased the sol–gel phase transition temperature in comparison with the chitosan chloride solution containing β-glycerophosphate.
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APPLICATION OF TEXTURE PROFILE ANALYSIS TO INVESTIGATE THE MECHANICAL PROPERTIES OF THERMOSENSITIVE INJECTABLE CHITOSAN HYDROGELS

81%
Owczarz P., Rył A., Wichłacz Ż.
Progress on Chemistry and Application of Chitin and its Derivatives
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2019
|
vol. 24
151 - 163
EN
In this paper, the mechanical properties of hybrid chitosan hydrogels were investigated using the texture profile analysis test. Scaffolds obtained from a polysaccharide of various molecular weights were studied, which, with the addition of glycerophosphate salt, formed a three-dimensional structure in vivo. The obtained systems were also enriched with collagen and calcium carbonate to improve the mechanical properties. The determined texture parameter values indicate that the mechanical properties of the hybrid hydrogel depend on the molecular weight of the polymer, the type of solvent and, the pH-neutralizing substance, as well as the type and concentration of the filler. Moreover, in some cases the TPA test was the only way to evaluate the mechanical properties of the obtained hydrogels due to the inability to determine the Young's modulus. Consequently, the texture analysis test is a valuable tool for selecting solutions depending on the intended application of the scaffolds.
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