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Białka kompleksu ADF/kofilina: regulacja dynamiki filamentów aktynowych

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Stępień A., Grzanka A., Ostrowski M.
Kosmos
|
2005
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vol. 54
|
issue 4
381-389
EN
Many cellular events are directly related to the cytoskeleton’s dynamics, which remain under control of the protein regulatory system. Proteins of the ADF/cofilin family have been shown to be active in depolymerizing F-actin, as well as severing actin filaments and creating free barbed ends. Their various functions are regulated, among others, by phosphorylation, pH, the state of the nucleotide bound profilin, gelsolin, tropomyosin, AIP1 and the Arp 2/3 complex. In addition, the ability of ADF/cofilin to bind to actin appears to be modified by phalloidin. It has also been emphasized that these key actin dynamics’ regulators are able to form intranuclear actin/cofilin rods and some of their activities are associated with apoptosis.
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Rak pęcherza moczowego - molekularne podłoże genezy i leczenia

100%
Izdebska M., Grzanka A., Ostrowski M.
Kosmos
|
2005
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vol. 54
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issue 2-3
213-220
EN
Bladder cancer is one of the most common human tumours.This malignancy develops in various tissues of the bladder. The disease is caused by several factors e.g. some chemical agents and radiation. Ingredients of smoke and numerous industrial chemicals play a role in cancer cells formation. Aromatic amines and some their derivatives introduce changes in DNA sequences. Mutations of some suppressor genes and protooncogenes (p53, Rb) may contribute to tumour transformation. Mitomycin C, adriamycin and other chemiotherapeutics destroy cancer cells acting on plasma membrane and mitochondrial apoptotic pathways. This review article presents the molecular basis of formation and of the mechanisms of urinary bladder.
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