Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 5

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Publication available in full text mode
Content available

Anticancer and Antioxidant Phytochemicals as Speed Breakers in Inflammatory Signaling

100%
Olajide P. A., Adetuyi O. A., Omowumi O. S., Adetuyi B. O.
World News of Natural Sciences
|
2022
|
vol. 44
231-259
EN
A causal association between inflammation and cancer has long been suspected. Multiple lines of compelling evidence from clinical, epidemiologic and laboratory studies support that inflammation plays a critical role in the promotion and progression stages of carcinogenesis. Recent progress in our understanding of the molecular biology of cancer highlights the intracellular signal transduction network, including that involved in mediating the inflammatory response, which often functions abnormally during carcinogenesis. One of the key players in inflammatory signaling is cyclooxygenase-2 (COX-2). Aberrant upregulation of COX-2 is frequently observed in various precancerous and malignant tissues. This seminar write-up highlights the cancer preventive effects of some anti-inflammatory phytochemicals derived from edible plants, and their underlying molecular mechanisms with a focus on representative transcription factors and upstream kinases responsible for COX-2 induction.
2
Publication available in full text mode
Content available

Involvement of Free Radicals in the Ageing of Cutaneous Membrane

88%
Adetuyi B. O., Adebayo P. F., Olajide P. A., Atanda O. O., Oloke J. K.
World News of Natural Sciences
|
2022
|
vol. 43
11-37
EN
The free radical theory of aging suggests that aging is caused by accumulation of damage inflicted by reactive oxygen species (ROS). However, this concept has been very useful in defining the contribution of oxidative damage to the aging process, an increasing number of studies opposes it. The idea that oxidative damage represents only one of many causes of aging also has limitations, as it does not explain causal relationships and inevitability of damage accumulation. Here, it is discussed that heterogeneity, infidelity and imperfectness of each and every biological process may be responsible for the inevitable accumulation of by-products and other damage forms. Although ROS are prototypical by-products, their contribution to aging is governed by the metabolic organization of the cell, its protective systems, and genotype. These factors are controlled by natural selection, dietary and genetic interventions that extend lifespan, change the composition of cumulative damage and the rates of accumulation of its various forms. Oxidative damage, like other specific damage types viewed in isolation or in combination, does not represent the cause of aging. Instead, biological imperfectness, which leads to inevitable accumulation of damage in the form of mildly deleterious molecular species, may help define the true root of aging. Free radical and other specialized damage theories served their purpose in the understanding of the aging process, but in the current form they limit further progress in this area.
3
Publication available in full text mode
Content available

Nutraceuticals: role in metabolic disease, prevention and treatment

76%
Adetuyi B. O., Odine G. O., Olajide P. A., Adetuyi O. A., Atanda O. O., Oloke J. K.
World News of Natural Sciences
|
2022
|
vol. 42
1-27
EN
Nutraceuticals are products that are also used as medicine other than nutrition. A nutraceutical product may be defined as a substance, which have physiological benefits nor gives protection against chronic diseases. Nutraceuticals may also be used to improve health, delay the aging process, prevent chronic disease, increase life expectancy, or support the structure or function of the body. Nowadays, nutraceuticals has gained considerable interest due to potential nutritional safety and therapeutic effects. Recent studies have shown promising results for those compounds in various complications. Emphasis has been made to present herbal nutraceuticals effective on hard curative disorders related to oxidative stress including allergy, Alzheimer, cardiovascular, cancer, diabetes, and Parkinson’s diseases as well as obesity.
4
Publication available in full text mode
Content available

Effect of Monosodium Glutamate on the Body System

76%
Adeleke D. A., Olajide P. A., Omowumi O. S., Okunlola D. D., Taiwo A. M., Adetuyi B. O.
World News of Natural Sciences
|
2022
|
vol. 44
1-23
EN
Worldwide, monosodium glutamate is utilized as a flavor enhancer and is composed of essential amino acids for nutrition. Numerous health issues are thought to be linked to monosodium glutamate. Studies have demonstrated that monosodium glutamate has harmful side effects, notably in animals, such as the development of obesity and diabetes as well as hepatotoxic, neurotoxic, and genotoxic consequences. According to several accounts, human subjects were becoming more ravenous, eating more, and becoming obese. Only a few human studies have been done to examine the potential genotoxic, neurotoxic, and hepatotoxic consequences of monosodium glutamate. Exploring the molecular and metabolic mechanisms relating to monosodium glutamate will need a lot of investigation.
5
Publication available in full text mode
Content available

Toxicological Significance of the Occurrence of Selenium in Foods

76%
Adewale G. G., Olajide P. A., Omowumi O. S., Okunlola D. D., Taiwo A. M., Adetuyi B. O.
World News of Natural Sciences
|
2022
|
vol. 44
63-88
EN
The presence of selenium (Se) in foods and the pertinent toxicological data are reviewed. In most regions of the world, the average daily intake of man is thought to be between 60 and 250 micrograms for adults and between 4 and 35 micrograms for infants. The current practice of adding selenium supplements to animal feeds may increase the selenium content of meats by up to 30%, but this does not result in a biologically meaningful increase in the selenium intake of people. Se is mostly absorbed after ingestion, according to the available metabolic data. Up to 50% of it is eliminated in the urine, while the remaining percentage builds up primarily in the liver and kidneys. Recent epidemiological and animal studies show that Se is not a carcinogen, and in some cases may have anti-cancer properties. Neither the essentiality for man, nor the no-effect level of Se have been established.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.