Results found: 3

Number of results on page

Search results

Sort By:

Limit search:

Microwave assisted reactions of 2-[3-(Trifluoromethyl)phenyl]-4-R1-furo[3,2-b] pyrrole-5-carboxhydrazides

100%

Gašparová R., Moncman M., Horváth B.

Open Chemistry

2008

vol. 6

issue 2

180-187

The effect of microwave irradiation on the reactions of 2-[3-(trifluoromethyl)phenyl]-4-R1-furo[3,2-b]pyrrole-5-carboxhydrazides 1 with 5-arylfuran-2-carboxaldehydes 2, thiophene-2-carboxaldehyde (3) and methyl 2-formylfuro[3,2-b]pyrrole-5-carboxylates 4 has been studied. Reactions of 1 with formic and acetic acid, respectively, led to acylhydrazides 9a–c. Reaction of 1a with 4-substituted 1,3-oxazol-5(4H)-one 10 led to imidazole derivative 13. 1,2,4-Triazole-3-thiones 15a,b were synthesized by two-step reaction of 1a with potassium isothiocyanate and phenyl isothiocyanate, respectively, and subsequent base-catalyzed cyclization of thiosemicarbazides 14a,b. Pyrazole 16 was prepared by reaction of 1a with pentane-2,4-dione. [...]

Synthesis and antimicrobial activity of a series of optically active quaternary ammonium salts derived from phenylalanine

76%

Lukáč M., Lacko I., Bukovský M., Kyselová Z., Karlovská J., Horváth B., Devínsky F.

Open Chemistry

2010

vol. 8

issue 1

194-201

We synthesized nine quaternary ammonium compounds (QUATs) starting from phenylalanine, N-alkyl-N,N-dimethyl-(1-hydroxy-3-phenylpropyl)-2-ammonium bromides, which were prepared as optically pure substances. Five compounds were prepared as S-enantiomers and four compounds as R-enantiomers. These compounds were evaluated by their activities against bacteria and fungi. Three microbial strains were used in the study: the gram-negative bacteria Escherichia coli, the gram-positive bacteria Staphylococcus aureus and the fungi Candida albicans. The activities were expressed as minimum bactericidal or fungicidal concentrations (MBC). The most active compounds were (2S)-N-tetradecyl-N,N-dimethyl-(1-hydroxy-3-phenylpropyl)-2-ammonium bromide and (2R)-N-tetradecyl-N,N-dimethyl-(1-hydroxy-3-phenylpropyl)-2-ammonium bromide, with MBC values exceeding those of commercial benzalkoniumbromide (BAB) used as standard. The relationships between structure and biological activity of the tested QUATs were quantified by the bilinear model (QSAR) and are discussed. [...]

Reactions of substituted furo[3,2-b]pyrrole-5-carboxhydrazides and their biological activity

76%

Ga, Zbojek D., Lácová M., Král'ová K., Gatial A., Horváth B., Krutošíková A.

Open Chemistry

2005

vol. 3

issue 4

622-646

The reactions of substituted furo[3,2-b]pyrrole-5-carboxhydrazides 1 with 5-arylfuran-2-carboxaldehydes 2, 4,5-disubstituted furan-2-carboxaldehydes 3 and thiophene-2-carboxaldehyde 4 has been studied. The advantage of microwave irradiation on some of these reactions was reflected in the reduced reaction time and increased yields. Reactions of 1 with 4-substituted 1,3-oxazol-5(4H)-ones 11 led to diacylhydrazines 13 or to imidazole derivatives 14 depending on the temperature. 1,2,4-Triazole-3-thione 17 was synthesized by two-step reaction of 1 with phenylisothiocyanate and subsequent base-catalyzed cyclization of thiosemicarbazide 16. The effects of hydrazones 5–10 on inhibition of photosynthetic electron transport in spinach chloroplasts and chlorophyll content in the antialgal suspensions of Chlorella vulgaris were investigated.

Refine search results

3 Open Chemistry

1 2010

1 2008

1 2005

3 Horváth B.

1 Bukovský M.

1 Devínsky F.

1 Ga

1 Gatial A.

1 Gašparová R.

1 Karlovská J.

1 Krutošíková A.

1 Král'ová K.

1 Kyselová Z.

1 Lacko I.

1 Lukáč M.

1 Lácová M.

1 Moncman M.

1 Zbojek D.

Search results

Microwave assisted reactions of 2-[3-(Trifluoromethyl)phenyl]-4-R1-furo[3,2-b] pyrrole-5-carboxhydrazides

Synthesis and antimicrobial activity of a series of optically active quaternary ammonium salts derived from phenylalanine

Reactions of substituted furo[3,2-b]pyrrole-5-carboxhydrazides and their biological activity