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In vitro hemocompatibility and corrosion behavior of new Zr-binary alloys in whole human blood

100%
Totea G., Ionita D., Demetrescu I., Mitache M.
Open Chemistry
|
2014
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vol. 12
|
issue 7
796-803
EN
The aim of this study is to evaluate the accuracy of three binary alloys’ composition, and their biocompatibility. Depending on the intended use of the medical devices made from these materials, dynamic or static tests should be performed. We have chosen static tests as we thought they may be used as knee or hip replacement, and not as cardiac valves. Three binary alloys ( Zr10Nb, Zr2.5Nb and Zr12Ta) were obtained from high purity powders (>99.9%), using an induction furnace first, and an electric arc furnace for a perfect homogenization. Their final composition was verified with a XRF analyzer-INNOV-X. Hemolysis tests can determine the degree of red blood cells lysis and the release of hemoglobin. The released hemoglobin quantity was extremely small, under 2%, in all cases, and the coagulation tests showed no risk for thrombosis. The electrochemical behavior was also studied in biological fluid, human female serum, and showed a low corrosion rate. The obtained alloys do not cause hemolysis, so they are hemocompatible with all blood types.
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Synthesis, characterization and controlled toxicity of a novel hybrid material based on cisplatin and docetaxel

76%
Prodana M., Voiculet A., Garea S., Radu M., Iovu H., Demetrescu I., Dinischiotu A.
Open Chemistry
|
2014
|
vol. 12
|
issue 10
1008-1015
EN
This paper is focused on the synthesis and characterization of a novel hybrid material based on cisplatin and docetaxel-loaded functionalized simultanously carbon nanotubes able to be used in cancer therapy as drug delivery system with controlled toxicity. This material was physico-chemically investigated by determining the structure, as evidenced by Fourier transform infrared (FTIR) spectroscopy, transmission electronmicroscopy (TEM) and its stability was studied with the aid of thermogravimetric analysis (TGA). The amount of platinum ions released into the solution of simulated body fluid (SBF) was highlighted by coupled plasma mass spectrometry (ICP-MS). Toxicology experiments were performed with MDA-MB 231 breast cancer epithelial cells. The performance of the new drug delivery hybrid material was compared with functionalised carbon nanotubes with therapeutic agents functionalized with a single therapeutic agent.
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