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Interaction of unmodified and partially silylated nanosilica with red blood cells

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Gun’ko V., Galagan N., Grytsenko I., Zarko V., Oranska O., Osaulenko V., Bogatyrev V., Turov V.

Open Chemistry

2007

vol. 5

issue 4

951-969

Interaction of red blood cells (RBCs) with unmodified and partially (50%) silylated fumed silica A-300 (nanosilica)was studied by microscopic, XRD and thermally stimulated depolarisation current (TSDC) methods. Nanosilica at a low concentration C A-300C A-300 = 1 wt% all RBCs transform into shadow corpuscles because of 100% haemolysis. Partial (one-half) hydrophobization of nanosilica leads to reduction of the haemolytic effect in comparison with unmodified silica at the same concentrations. A certain portion of the TSDC spectra of the buffered suspensions with RBC/A-300 is independent of the amounts of silica. However, significant portions of the low-and high-temperature TSDC bands have a lower intensity at C A-300 = 1 wt% than that for RBCs alone or RBC/A-300 at C A-300 = 0.01 wt.% because of structural changes in RBCs. Results of microscopic and XRD investigations and calculations using the TSDC-and NMR-cryoporometry suggest that the intracellular structures in RBCs (both organic and aqueous components) depend on nanosilica concentration in the suspension. [...]

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1 Open Chemistry

1 2007

1 Bogatyrev V.

1 Galagan N.

1 Grytsenko I.

1 Gun’ko V.

1 Oranska O.

1 Osaulenko V.

1 Turov V.

1 Zarko V.

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Interaction of unmodified and partially silylated nanosilica with red blood cells