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Regulation of cellular differentiation and cellular function by phosphatidylinositol 3-kinase ? a reevaluation

100%

Ptasznik A.

Postępy Higieny i Medycyny Doświadczalnej

2000

vol. 54

issue 5

609-618

Phosphatidylinositol 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of cell growth/differentiation and cellular function. Several pathways have been recently identified and this article summarizes current knowledge about them. Depending on cell type the PI3K pathway has been involved in positive or negative regulation of differentiation. Products of PI3Ks and other signalling intermediates are shared between the G protein-coupled receptors and receptor tyrosine kinases, suggesting that control of differentiation and growth is equally dependent on these two distinct classes of receptors. Thus, the role of PI3Ks in the regulation of differentiation is clearly a very complex process implicating integration between different receptor systems and cell type-specific responses.

Crosstalk between G protein-coupled receptors and tyrosine kinase signaling: Src take centre stage

63%

Ptasznik A., Gewirtz A. M.

vol. 48

issue 1

27-30

Although the role of G protein-coupled receptors in the regulation of metabolic, secretory and contractile responses is well established, they have only recently been recognized as important mediators of cellular growth and differentiation. G protein-coupled signaling pathways had been previously thought to be totally independent of the tyrosine kinase receptor pathway. It was previously believed that molecular switches responsible for growth factor tyrosine kinase receptor signaling and G protein-coupled signaling were divided into a distinct sets of protein families. Recent evidence has demonstrated, however, that G protein-coupled receptors can crosstalk to tyrosine kinase signaling. In the past few years several groups have found that G protein-coupled receptors utilize non-receptor tyrosine kinases, mostly that of Src family, and some adapter proteins, to regulate tyrosine kinase cascades in cells.

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1 Archivum Immunologiae et Therapiae Experimentalis

1 Postępy Higieny i Medycyny Doświadczalnej

2 2000

2 Ptasznik A.

1 Gewirtz A. M.

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Regulation of cellular differentiation and cellular function by phosphatidylinositol 3-kinase ? a reevaluation

Crosstalk between G protein-coupled receptors and tyrosine kinase signaling: Src take centre stage