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Genes and enzymes taking part in biotransformation of steroid ring structure

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Brzostek A., Poplawski T., Murooka Y., Dziadek J.
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EN
Biotransformation of steroid compounds involves two major steps: side chain degradation, which is poorly understood at the genetic level, and the degradation of steroid ring structure, which is better known. This article describes well known molecular mechanisms of ring structure multistep biodegradation. Particular stress is put on the role of cholesterol oxidase, ketosteroid dehydrogenase, ketosteroid isomerase as the best analysed enzymes involved in steroid biotransformation.
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