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Cefoselina – nowa cefalosporyna czwartej generacji

100%
Zalewski P., Cielecka-Piontek J.
Annales Academiae Medicae Silesiensis
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2011
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vol. 65
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issue 3
77-81
EN
Cefoselis sulphate is a new parenteral cephalosporin, which was launched into therapy in Japan on 9 September, 1998. Cefoselis, like all the other beta-lactams, exhibits its bactericidal eff ects by binding to penicillinbinding proteins. It has a spectrum of activity that covers aerobic and anaerobic gram-positive and gram-negative bacteria. Cefoselis has been approved to treat infections caused by Staphylococcus and Pseudomonas especially respiratory and urinary tract infections. The recommended dose of cefoselis is 1 g twice a day as an intravenous infusion. The duration of therapy is from 5 to 14 days.
PL
Siarczan cefoseliny jest nową cefalosporyną do podawania parenteralnego, wprowadzoną do lecznictwa w Japonii 9 sierpnia 1998 r. Cefoselina, jak inne betalaktamy, działa przeciwbakteryjnie przez łączenie się z białkami wiążącymi penicylinę. Wykazuje spektrum działania wobec bakterii tlenowych i beztlenowych Gram-dodatnich oraz Gram-ujemnych. Wskazana jest w leczeniu infekcji wywołanych przez Staphylococcus i Pseudomonas, a zwłaszcza w zakażeniach dróg oddechowych i moczowych. Zalecane dawkowanie cefoseliny to 1 g dwa razy dziennie w postaci wlewu dożylnego. Czas trwania terapii 5–14 dni.
2
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Development and validation of the stability-indicating LC-UV method for the determination of cefoselis sulphate

81%
Zalewski P., Cielecka-Piontek J., Jelińska A.
Open Chemistry
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2012
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vol. 10
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issue 1
121-126
EN
The stability-indicating LC assay method was developed and validated for quantitative determination of cefoselis sulphate in the presence of degradation products formed during the forced degradation studies. An isocratic, RP-HPLC method was developed with C-18 (250 × 4.6 mm, 5 µm) column and 12 mM ammonium acetate-acetonitrile (95:5 V/V) as a mobile phase. The flow rate of the mobile phase was 1.0 mL min−1. Detection wavelength was 260 nm and temperature was 30°C. Cefoselis similarly to other cephalosporins was subjected to stress conditions of degradation in aqueous solutions including hydrolysis, oxidation, photolysis and thermal degradation. The developed method was validated with regard to linearity, accuracy, precision, selectivity and robustness. The method was applied successfully for identification and determination of cefoselis sulphate in pharmaceuticals and during kinetic studies.
3
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Development of the UHPLC-DAD method for simultaneous determination of four active pharmacological ingredients in cannabinoid plant material

61%
Zalewski P., Krause A., Milewski M., Wielgus K., Szalata M., Słomski R., Piontek J. C.
Acta Poloniae Pharmaceutica - Drug Research
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2018
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vol. 75
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issue 4
885-890
EN
A stability-indicating ultra-high-performance liquid chromatography (UHPLC) with DAD detector was developed and validated for the simultaneously determination of Δ9-tetahydrocannabitol (THC), cannabidiol (CBD), Δ9-tetahydrocannabinolic acid (THC-COOH) and cannabidiolic acid (CBD-COOH) in extracts of Cannabis sativa L.. The separation was achieved on a Kinetex, C18, 100 x 2.1 mm, 2.6 µm. The gradient separation was started with mixture of methanol and 12mM ammonium acetate in ratio 75:25 (%/%). The methanol was increased to 100% from 0.0 min to 10.0 min, then maintained 100% for the next 1.0 min, then decreased to 75% from 11.0 min to 15.0 min and held at 75% from 15.0 min to 20.0 min. The injection volume was 5.0 µL and the wavelength of detection was controlled at 228 nm.
4
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THE RADIOLYTIC STUDIES OF DORIPENEM MONOHYDRATE IN THE SOLID STATE

61%
Zalewski P., Kilińska K., Piontek J. C., Skibiński R., Szymanowska D., Miklaszewski A., Bednarski W.
Acta Poloniae Pharmaceutica - Drug Research
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2018
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vol. 75
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issue 5
1127-1133
EN
The influence of ionising radiation on physicochemical properties of doripenem in solid state was studied. No changes for doripenem irradiated with a dose of 25 kGy, required to attain sterility, was observed by FT-IR and chromatographic methods, although the presence of free radicals (7.7*1017 radicals/g) was detected by EPR. The antibacterial activity of doripenem irradiated with a dose of 25 kGy was unchanged. Solid doripenem has proven to be very stable on irradiation, and irradiation has been found to be a suitable method for its sterilization.
5
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THE RADIATION STERILIZATION OF IMIPENEM AND CILASTATIN IN THE SOLID STATE

61%
Zalewski P., Kilińska K., Piontek J. C., Miklaszewski A., Szymanowska D., Skibiński R., Bednarski W.
Acta Poloniae Pharmaceutica - Drug Research
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2019
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vol. 76
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issue 3
431-438
EN
One of the best sterilization methods for chemically unstable drugs, such as carbapenems, is irradiation. The chemical and physical properties of radiosterilized imipenem and cilastatin were analyzed using spectrophotometric and chromatographic methods. Unstable free radicals were presented in samples after irradiation; their mean lifetime was 142±64 h. The antibacterial activity of cefozopran hydrochloride irradiated with a dose of 25 kGy changed for Klebsiella pneumoniae and Escherichia coli. Imipenem and cilastatin in the solid state are not resistant to radiation sterilization; therefore, this method cannot be used for sterilization of this compound.
6
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THE RADIOSTABILITY OF BETAMIPRON IN THE SOLID STATE

61%
Zalewski P., Kilińska K., Cielecka-Piontek J., Skibiński R., Miklaszewski A., Bednarski W.
Acta Poloniae Pharmaceutica - Drug Research
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2019
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vol. 76
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issue 4
629-634
EN
The influence of ionising radiation on physicochemical properties of betamipron in solid state was studied. No changes for betamipron irradiated with a dose of 25 kGy, required to attain sterility, was observed by spectroscopic and chromatographic methods. Solid betamipron has proven to be very stable on irradiation, and irradiation has been found to be a suitable method for its sterilization.
7
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The radiolytic studies of panipenem in the solid state

52%
Zalewski P., Rosiak N., Kilińska K., Skibiński R., Szymanowska D., Tykarska E., Piekara-Sady L., Lewandowska K., Miklaszewski A., Piontek J. C.
Acta Poloniae Pharmaceutica - Drug Research
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2020
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vol. 77
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issue 2
241-250
EN
The influence of ionizing radiation on the physicochemical properties of panipenem in solid state was studied. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile panipenem. Spectroscopic (FT-IR, Raman), chromatography (HPLC and HPLC-MS) and X-ray powder diffraction (XRPD) studies have shown that irradiation of ertapenem with the 25 kGy, the dose required to achieve sterility, does not change the physicochemical properties of the studied compound. The antimicrobial activity of panipenem irradiated with the dose of 25 kGy was reduced for three species. It was confirmed that the decrease in antimicrobial activity might be related to isomerization of panipenem.
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