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Chromosome 7q11 controls sperm beat cross frequency (BCF) in mice

100%
Golas A., Grzmil P., Muller C., Styrna J.
Folia Biologica
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2004
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vol. 52
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issue 3-4
211-217
EN
The aim of this study was to compare the inheritance of the chromosomal SSLP markers with the inheritance of sperm movement parameters in order to map genes responsible for these quantitative traits (QTs). Chromosome 7 and 14 SSLP markers were tested to obtain the strain distribution pattern (SDP) for recombinant inbred (RI) strains developed from two progenitors, KE and CBA/Kw, which differ significantly in gamete quality. Sperm motility characteristics were determined using the computer assisted semen analysis (CASA) system. The Map manager software was used in order to assess linkage between the analyzed motility parameters and chromosome regions. The marker regression, interval mapping and permutation tests matched the QT loci of BCF with chromosome 7q11. The likelihood ratio statistic for this association was 18.1 with 79% of the total trait variance explained by QTL at this locus. These mapping results suggest that the BCF trait depends on the genetic factor(s) located in this region.
2

Mast cells and inflammation

100%
Stassen M., Hultner L., Muller C., Schmitt E.
Archivum Immunologiae et Therapiae Experimentalis
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2002
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vol. 50
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issue 3
179-186
EN
Mast cells have long since been recognized as potent producers of a large panel of biological highly active mediators such as biogenic amines, arachidonic acid metabolites, cytokines and chemokines, but most of their biological functions had been elusive and speculative. By taking advantage of mast cell-deficient mice, the role of mast cells in a variety of experimental settings can now be studied in detail and such approaches have dramatically altered and enlarged our knowledge about mast cell biology and function. Herein we will focus on the role of mast cells in inflammatory reactions of diverse origin such as delayed type hypersensitivity, atopy, immune complex-mediated inflammation and innate immune responses. From a current point of view, there is no doubt that the most outstanding and beneficial feature of mast cells is their recently uncovered ability to rapidly induce a life-saving inflammatory response upon encountering microbes and microbial constituents. Nevertheless, the picture is also emerging that mast cells are deeply involved in the induction and maintenance of a variety of severe allergic and autoimmune diseases. However, a deeper understanding of their activation and immune-modulatory capacity might open a new window for the development of curative strategies.
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