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Organometallic iron complexes as potential cancer therapeutics

100%

Mojžišová G., Mojžiš J., Vašková J.

Acta Biochimica Polonica

2014

vol. 61

issue 4

651-654

Metal-containing drugs have long been used for medicinal purposes in more or less empirical way. The potential of these anticancer agents has only been fully realised and explored since the discovery of the biological activity of cisplatin. Cisplatin and carboplatin have been two of the most successful anti-cancer agents ever developed, and are currently used to treat ovarian, lung and testicular cancers. They share certain side effects, so their clinical use is severely limited by dose-limiting toxicity. Inherent or acquired resistance is a second problem often associated with platinum-based drugs, with further limits of their clinical use. These problems have prompted chemists to employ different strategies in development of the new metal-based anticancer agents with different mechanisms of action. There are various metal complexes still under development and investigation for the future cancer treatment use. In the search for novel bio-organometallic molecules, iron containing anti-tumoral agents are enjoying an increasing interest and appear very promising as the potential drug candidates. Iron, as an essential cofactor in a number of enzymes and physiological processes, may be less toxic than non essential metals, such as platinum. Up to now, some of iron complexes have been tested as cytotoxic agents and found to be endowed with an antitumor activity in several in vitro tests (on cultured cancer cell lines) and few in vivo experiments (e. g. on Ehrlich's ascites carcinoma). Although the precise molecular mechanism is yet to be defined, a number of observations suggest that the reactive oxygen species can play important role in iron-induced cytotoxicty. This review covers some relevant examples of research on the novel iron complexes.

The influence of various sport activities on the degeneration of intervertebral discs

76%

Rapčan R., Poliak Ľ., Rapčanová S., Lenčéš P., Buriánek M., Vašková J., Kočan L.

Polish Journal of Sports Medicine

2020

vol. 36(3)

115-121

Excessive physical activity is one of the main risk factors in the formation of degenerative changes of the intervertebral discs. Recreational and elite sport also represents a repeated increased physical load, and based on the type of sport, a more intense and sometimes less intense action of direct forces on the intervertebral discs. On the other hand, sport and training is in general regarded as beneficial for our health. Many doctors also regards sport as a form of prevention against back injuries. The authors analyze numerous sporting activities with different types of direct forces acting on the spine, with the goal to inform on realistic scientific facts regarding the impact of these activities on the degeneration of the intervertebral disc. They inform about the available facts, which confirm the positive effects of a certain type of sport load on the degeneration of the intervertebral disc, and its correlation with the clinically manifested back pain.

Antiproliferative effect of β-escin - an in vitro study

64%

Mojžišová G., Kello M., Pilátová M., Tomečková V., Vašková J., Vaško L., Bernátová S., Mirossay L., Mojžiš J.

Acta Biochimica Polonica

2016

vol. 63

issue 1

79-87

This study examined the antiproliferative effects of β-escin (E) in cancer cells. The study showed that E inhibited cancer cells growth in a dose-dependent manner. The flow cytometric analysis revealed an escin-induced increase in the sub-G1 DNA content, which is considered to be a marker of apoptosis. Apoptosis was also confirmed by annexin V staining and DNA fragmentation assay. These effects were associated with increased generation of reactive oxygen species (ROS), caspase-3 activation and decreased mitochondrial membrane potential (MMP). Moreover, escin decreased mitochondrial protein content and mitochondrial fluorescence intensity as well as caused depletion of glutathione (GSH). However, activity of glutathione peroxidase (GPx) and glutathione reductase (GR) was not significantly changed in escin-treated cells. In conclusion, our results demonstrated that E has apoptotic effects in human cancer cells through the mechanisms involving mitochondrial perturbation. Although the exact mechanism needs to be investigated further, it can be concluded that E may be a useful candidate agent for cancer treatment.

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2 Acta Biochimica Polonica

1 Polish Journal of Sports Medicine

1 2020

1 2016

1 2014

3 Vašková J.

2 Mojžiš J.

2 Mojžišová G.

1 Bernátová S.

1 Buriánek M.

1 Kello M.

1 Kočan L.

1 Lenčéš P.

1 Mirossay L.

1 Pilátová M.

1 Poliak Ľ.

1 Rapčan R.

1 Rapčanová S.

1 Tomečková V.

1 Vaško L.

Search results

Organometallic iron complexes as potential cancer therapeutics

The influence of various sport activities on the degeneration of intervertebral discs

Antiproliferative effect of β-escin - an in vitro study