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Kinetics of a nucleoside release from lactide-caprolactone and lactide-glycolide polymers in vitro.

100%

Kryczka T., Grieb P., Bero M., Kasperczyk J., Dobrzynski P.

2000

vol. 47

issue 1

59-64

We assessed the rate of release of a model nucleoside (adenosine, 5%, w/w) from nine different lactide-glycolide or lactide-caprolactone polymers. The polymer discs were eluted every second day with an artificial cerebrospinal fluid at the elution rate roughly approximating the brain extracellular fluid formation rate. Adenosine in eluate samples was assayed by HPLC. Three polymers exhibited a relatively constant release of adenosine for over four weeks, resulting in micromolar concentrations of nucleoside in the eluate. This points to the neccessity of further development of polymers of this types as intracerebral nucleoside delivery systems for local treatment of brain tumors.

In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers.

86%

Kryczka T., Bero M., Kasperczyk J., Dobrzyński P., Marciniec B., Popierzal-Brzezińska M., Grieb P.

2002

vol. 49

issue 1

205-210

The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37°C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire observation period. Sterilization with either ethylene oxide or gamma radiation only slightly influenced nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indicated.

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2 Acta Biochimica Polonica

1 2002

1 2000

2 Bero M.

2 Grieb P.

2 Kasperczyk J.

2 Kryczka T.

1 Dobrzynski P.

1 Dobrzyński P.

1 Marciniec B.

1 Popierzal-Brzezińska M.

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Kinetics of a nucleoside release from lactide-caprolactone and lactide-glycolide polymers in vitro.

In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers.