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STABILITY STUDIES OF CEFTIOFUR SODIUM IN AQUEOUS SOLUTIONS AND IN THE SOLID PHASE

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Dołhań A., Sobczak A., Muszalska I., Medenecka B., Garbacki P., Tomczak S., Jelińska A.

Acta Poloniae Pharmaceutica - Drug Research

2018

vol. 75

issue 6

1279-1286

Ceftiofur sodium (CFT), a third-generation cephalosporin for parenteral use, is commonly used in veterinary medicine against aerobic Gram-positive and Gram-negative bacteria as well as certain anaerobes. Its broad spectrum of activity and resistance to beta-lactamases result from the presence of methoxyimino and aminothiazole moieties at C-7 in the cephalosporin structure. The aim of this study was a comprehensive evaluation of the stability of CFT in the solid phase and in aqueous solutions. A fast and sensitive HPLC isocratic method was used for the determination of CFT degradation in the solid phase and in aqueous solutions. CFT degradation occurred according to a first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of CFT degradation in the solid phase were calculated. General acid-base hydrolysis of CFT was not observed in the solutions of hydrochloric acid, sodium hydroxide, phosphate (pH 5.84 – 7.25), acetate (pH 3.65 – 5.48) and borate (pH 7.49 – 10.07) buffers. CFT was the most stable in the pH range 2 – 6. The susceptibility of CFT to degradation under the influence of stress factors (pH, temperature, buffer components concentration, relative air humidity) should be considered in terms of storage conditions and the preparation of the product for administration.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 2018

1 Dołhań A.

1 Garbacki P.

1 Jelińska A.

1 Medenecka B.

1 Muszalska I.

1 Sobczak A.

1 Tomczak S.

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STABILITY STUDIES OF CEFTIOFUR SODIUM IN AQUEOUS SOLUTIONS AND IN THE SOLID PHASE