Search results

Sort By:

Limit search:

Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors

100%

Liebrich M., Guo L.-H., Schluesener H. J., Schwab J. M., Dietz K., Will B. E., Meyermann R.

2007

vol. 55

issue 1

41-47

Introduction: Macrophages/microglial cells are considered as immune cells in the central nervous system. Interleukin (IL)-16 is a proinflammatory cytokine produced by activated monocytic cells. Materials and Methods: Expression of IL-16 was analyzed by immunohistochemistry in human astrocytic brain tumors and the rat C6 glioblastoma tumor model. IL-16 was detected in both human astrocytic brain tumors and rat C6 glioma. Results: Compared with human control brains, a significant increase in the percentages of parenchymal IL-16+ macrophages/microglia was observed already in grade II astrocytomas, indicating that IL-16+ immunostaining could be a descriptor of a macrophage/microglia subset in astrocytic brain tumors. A further increase was observed at the transition from grade II to III astrocytomas. This increase in IL-16 immunoreactivity correlated with WHO grades of human astrocytic brain tumors. Conclusions: Therefore, IL-16 might be a so far unknown factor in the regulation of the local inflammatory milieu of human and experimental astrocytomas.

Refine search results

1 Archivum Immunologiae et Therapiae Experimentalis

1 2007

1 Dietz K.

1 Guo L.-H.

1 Liebrich M.

1 Meyermann R.

1 Schluesener H. J.

1 Schwab J. M.

1 Will B. E.

Search results

Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors