Search results

Sort By:

Limit search:

Stereoselective preparation of mono- and bis-derivatives of pentacyclo[6.3.0.02,6.03,10.05,9] undecane (D 3-trishomocubane)

100%

Mishura A., Sklyarova A., Sharapa D., Levandovsky I., Serafin M., Fokin A., Rodionov V.

Open Chemistry

2013

vol. 11

issue 12

2144-2150

The rearrangement of easily accessible Cookson’s diketone with chlorosulfonic acid in chloroform followed by the acidic hydrolysis gave 6-chloro-7-hydroxy-dichloropentacyclo[6.3.0.02,6.03,10.05,9]undecane-4-one, whose syn-stereochemistry was assigned through the X-ray crystal structure analysis. This key structure was used for the stereoselective synthesis of the D 3-trishomocubane derivatives as well as for the preparation of potential drugs bearing hydroxy- and amino-functional groups. A new multigram preparative synthesis of D 3-trishomocubane was developed. [...]

Refine search results

1 Open Chemistry

1 2013

1 Fokin A.

1 Levandovsky I.

1 Mishura A.

1 Rodionov V.

1 Serafin M.

1 Sharapa D.

1 Sklyarova A.

Search results

Stereoselective preparation of mono- and bis-derivatives of pentacyclo[6.3.0.02,6.03,10.05,9] undecane (D 3-trishomocubane)