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1

The role of galanin in physiological and pathological processes in a human body

100%
Zdrojewicz Z., Sowinska E.
Postępy Higieny i Medycyny Doświadczalnej
|
2000
|
vol. 54
|
issue 6
819-834
EN
Galanin (GAL) a 29 amino-acid peptide, is distributed in the central and peripheral nervous system, the pituitary gland the gastrointestinal tract and also in the endocrine and exocrine pancreas. The endogenous and exogenous effects of galanin are mediated by three receptor subtypes, which are termed: GALR1, GALR2, GALR3. Galanin has a significant role in physiological and pathological processes (acromegally, diarhoea, collitis, Alzheimer?s disease, oberitas depression, pituitary gland adenomas) in a human body and animals. It has an ability to contract smooth muscles in gastrointestinal tract, stimulates reflexes in the central nervous system, decreases pancreatic amylase, release changes transport of elektrolytes Na+ and Cl-, exerts tonic inhibition of nociceptive input to the central nervous system, stimulates glucagon release, inhibits insulin and somatostatin release, takes part in prolactin secretion, stimulates growth hormone ? releasing hormone, hypothalamic gonadotropin releasing hormone and corticotropinreleasing hormone. It causes increase of somatotropin secretion,foliculotropin and luteinizing hormone release and adrenocorticotropin secretion.
2

Katacalacine - structure, secretion and clinical significance

100%
Zdrojewicz Z., Januszewski A.
Postępy Higieny i Medycyny Doświadczalnej
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1994
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vol. 48
|
issue 4
371-379
EN
Our review summerizes today's knowledge and the structure, secretion and clinical significance of katacalcine, a new C-terminal peptide from calcitonin gene.
3

Calcitonin gene-related peptide

81%
Zdrojewicz Z., Bolanowski M., Drumlak G., Januszewski A.
Postępy Higieny i Medycyny Doświadczalnej
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1995
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vol. 49
|
issue 2
237-252
4

Cholecystokinin hormone and neuromodulator

81%
Zdrojewicz Z., Sztuka-Pietkiewicz A., Pietkiewicz W.
Postępy Higieny i Medycyny Doświadczalnej
|
2001
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vol. 55
|
issue 3
407-418
EN
Cholecystokinin (CCK) is a polipeptyde having many functions in digestive system (regulating motor activity and secretion) and acting as a neuromodulator in central and peripheral nervous systems. Recent research shows that CCK increases insulin and glukagon secretion and activates hypothalamo- pituitary- adrenal axis. It also plays a role in cardiovascular system (CCK has a positive inotropic effect). The aim of this study is to show some recent knowledge in the subject of CCK structure and its function in human body.
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