There are many anatomic variations of pancreatic duct and congenital anomalies of pancreas, which have been described in the literature. Most of them has no clinical significance and is used to be incidentally discovered in radiological examinations. We have demonstrated in our paper that the most frequent anatomical variations of pancreatic duct in the patients with pancreatic diseases are pancreas divisum as well as ansa pancreatica.
There are many anatomic variations of pancreatic duct and congenital anomalies of pancreas, which have been described in the literature. Most of them has no clinical significance and is used to be incidentally discovered in radiological examinations. We have demonstrated in our paper that the most frequent anatomical variations of pancreatic duct in the patients with pancreatic diseases are pancreas divisum as well as ansa pancreatica.
The paper presents description of the effective treatment of patients with extensive consequences of necrotizing pancreatitis. The strategy of treatment was to extend access to necrotic areas („step-up approach”). Applied endoscopic transmural access (transgastric), percutaneous access (transperitoneal) and surgical access. The cooperation endoscopist, surgeon and interventional radiologist gave very beneficial clinical effects in patients with extensive complications of acute pancreatitis.
Background We can observe an increase in acute pancreatitis (AP) incidence in the recent years. Material and methods Retrospective clinical data analysis of 370 patients with AP, hospitalized between 2007 and 2016 at our Department. Results AP was diagnosed during 406 hospitalisation in 370 patients [average age 52.15 (21-93), 237(64.05%) male]. AP of high clinical severity was diagnosed in 60/370 (16.22%) patients. Average time of hospitalisation was 16.13 (1-121) days. Mortality was 12/406 (2.96%). The after effect of AP in form of parapancreatic fluid reservoirs was diagnosed in 202/406 (54.59%) cases. Comparing the early phase of the study (2007-2011) and the later one (2012-2016) a shorter time of hospitalisation was proven and a lower mortality of the patients in the later phase of the study. Analysis of patients' blood tests revealed that patients with severe AP have significantly elevated levels of inflammatory parameters and amylase comparing to group with mild and moderate AP, during the first days of hospitalisation. Conclusions The development of conservative treatment options for AP, especially in early stages of the illness, has significantly shortened the duration of hospitalisation of patients with AP at our Department.
The aim of the study. Investigation of the effect of vertical banded gastroplasty (VBG), which is an effective method of treating patients with morbid obesity on serum paraoxonase (PON) activity.Material and methods. Serum PON activity was measured in twenty eight morbidly obese patients 6 and 12 months after surgery. PON activity was also measured in the serum and liver of rats maintained on a restricted diet for one month.Results. We found that VBG-induced significant reduction in body weight and serum PON activity at 6 and 12 months after surgery. Similar patterns of decreases in serum paraoxonase activity in obese patients after VBG were observed in A, AB and B paraoxonase/esterase phenotypes. After VBG, several clinically relevant events occurred: a) a decrease of serum triacylglycerol concentration was observed; b) no significant changes in total serum cholesterol and LDL-cholesterol concentrations were found; c) serum HDL-cholesterol concentration increased slightly.Paraoxonase activity in the serum of rats maintained on a restricted diet, which induced approximately 30% and 50% of rat body weight and fat mass loss, respectively, was lower than in control animals.Conclusions. This study indicates that after VBG significant decreases in serum paraoxonase activity occur in obese subjects. It is likely that less food ingestion and possibly a different type of food consumed by the obese subjects after VBG (compared to type of food consumed before surgery) may contribute to decreases in serum PON activity.
Background: We can observe an increase in acute pancreatitis (AP) incidence in the recent years. Material and methods: Retrospective clinical data analysis of 370 patients with AP, hospitalized between 2007 and 2016 at our Department. Results: AP was diagnosed during 406 hospitalisation in 370 patients [average age 52.15 (21-93), 237(64.05%) male]. AP of high clinical severity was diagnosed in 60/370 (16.22%) patients. Average time of hospitalisation was 16.13 (1-121) days. Mortality was 12/406 (2.96%). The after effect of AP in form of parapancreatic fluid reservoirs was diagnosed in 202/406 (54.59%) cases. Comparing the early phase of the study (2007-2011) and the later one (2012-2016) a shorter time of hospitalisation was proven and a lower mortality of the patients in the later phase of the study. Analysis of patients' blood tests revealed that patients with severe AP have significantly elevated levels of inflammatory parameters and amylase comparing to group with mild and moderate AP, during the first days of hospitalisation. Conclusions: The development of conservative treatment options for AP, especially in early stages of the illness, has significantly shortened the duration of hospitalisation of patients with AP at our Department.
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