Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 32

Number of results on page
first rewind previous Page / 2 next fast forward last

Search results

help Sort By:

help Limit search:
first rewind previous Page / 2 next fast forward last
1
Publication available in full text mode
Content available

THE EFFECT OF A POLYVINYL ALCOHOL AND DEXTRANE ON THE PROPERTIES OF THERMOSENSITIVE HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2011
|
vol. 16
99 - 104
EN
Gels containing lactic acid complexed with chitosan at a stoichiometric ratio 1:1 and 2:1 and 5 - 25% content of polyoxyethylene glycol 200 reveal pH from 2.5 to 4.6. The addition of 20 – 25% poloxamer 407 increases the pH to 4.55 to 5.30 for 1:1 gels and 4.00 to 4.85 for 2:1 gels. The addition of 0.5% polyvinyl alcohol decreases the pH of the investigated gels to 4.00 to 4.55 for 1:1 gels and 3.85 to 4.40 for 2:1 gels. The addition of 1.0% dextrane decreases the pH of investigated gels to 4.40 to 4.90 (1:1) and 4.00 to 4.48 (2:1). Rheological investigations revealed an increase in the dynamic viscosity of preparations containing poloxamer 407 with the addition of polyvinyl alcohol or dextrane in comparison to the reference gels. Results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
2
Publication available in full text mode
Content available

EFFECT OF A DEXTRANE AND HYDROPHILIZING SUBSTANCES ON THE PROPERTIES OF THERMOSENSITIVE HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2013
|
vol. 18
|
issue 18
115-122
EN
Gels containing lactic acid complexed with chitosan at a stechiometric ratio 1:1 and 2:1 and 5-25% content of PEG-200 reveal pH from 3.42 to 4.95. The addition of 20 – 25% poloxamer 407 increases the pH from 4.55 to 5.30 for 1:1 gels and from 4.00 to 4.85 for 2:1 gels. The addition of 1.0% dextrane decreases the pH of investigated gels from 4.40 to 4.90 (1:1) and from 4.00 to 4.48 (2:1). The addition of poloxamer 407 at concentrations of 20 to 25% increases the dynamic viscosity from 506.14 to 641.20 for 1:1 and from 540.35 to 692.55 for 2:1 ratios. The addition of 1.0% dextrane increases the dynamic viscosity from 665.23 to 750.28 for 1:1 and from 645.50 to 740.16 for 2:1 ratios. The addition of dextrane and glycerol or 1,2-propylene glycol reduces the pH and maintains high adhesion. The use of dextrane and hydrophilizing substances allowed to obtain physiological range pH.
3
Publication available in full text mode
Content available

INFLUENCE OF PECTIN AND CHITOSAN ON THE PROPERTIES OF GELS PROTECTING THE OESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2021
|
vol. 26
162-169
EN
Among the diseases of the digestive tract, gastro-oesophageal reflux is one of the most troublesome ailments. It is estimated that in highly developed countries, reflux symptoms occur in about 5%-10% of people every day. It has also been found that about 20% of people experience such symptoms once a week. The incidence of this disease increases with age, regardless of gender. The aim of the study was to investigate the physicochemical properties of gels intended for the protection of the oesophageal mucosa. Preparations containing 3.0% pectin showed the lowest pH. These gels can be used in the treatment of advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of pectin concentration on the adhesion work of the tested gels.
4
Publication available in full text mode
Content available

PHARMACEUTICAL ASSESSMENT OF THERMOSENSITIVE HYDROPHILIC GELS WITH POLYVINYL PYRROLIDONE K-30 CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2013
|
vol. 18
|
issue 18
123-131
EN
Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5-25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm. Measurements performed in a biopharmaceutical model revealed that the addition of 20% poloxamer 407 to gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 decreases their movability from 20 to 25 cm and at 2:1 ratio, from 22 to 28 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 20 to 24 cm. The addition of 5% PVP K-30 besides 1,2-propylene glycol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 24 cm to 28 cm and at 2:1 ratio from 26 cm to 30 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 24 to 27 cm
5
Publication available in full text mode
Content available

CHITOSAN GELS TO PREVENT REFLUX DISEASE

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2023
|
vol. 28
103-110
EN
Reflux disease is one of the most frequently diagnosed conditions in developed countries. The problem is both the acidic content of the stomach and the alkaline content of the intestines. In each case, the oesophageal mucosa is destroyed. I analysed hydrogels that prevent irritation of the oesophageal mucosa. Specifically, I investigated the effect of chitosan and sodium alginate on the properties of gels protecting the oesophagus. Gels containing chitosan and 1.0% sodium alginate can be used to treat advanced alkaline reflux. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity, making it possible to neutralise acid reflux. Texture studies showed the influence of chitosan and sodium alginate on the adhesiveness of the tested gels.
6
Publication available in full text mode
Content available

THE EFFECT OF A CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

100%
Małolepsza-Jarmołowska K.
|
|
vol. 23
120 - 129
EN
The investigated powders on a methylcellulose base revealed good adhesion to the vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of the 24-hour action of the drug. The treatment of vagina inflammatory conditions is usually long and difficult because of the frequent relapse. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of lactic acid to chitosan of 1:1 and 2:1 showed a pH in the physiological range at 37°C. Additionally, carboxymethylcellulose sodium salt and excipients allow various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and carboxymethylcellulose sodium salt in comparison to gels without carboxymethylcellulose sodium salt.
7
Publication available in full text mode
Content available

SELECTED PHARMACEUTICAL PROPERTIES OF THERMOSENSITIVE HYDROPHILIC GELS WITH HYDROXYPROPYLMETHYLCELLULOSE CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2013
|
vol. 18
|
issue 18
131-138
EN
Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5-25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm. The addition of 4% hydroxypropylmethylcellulose besides glycerol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 25 cm to 28 cm and at 2:1 ratio from 27 cm to 30 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 24 to 29 cm The addition of 5-25% glycerol decreases the pH of investigated gels from 3.95 to 4.45 (1:1) and from 3.63 to 4.30 (2:1). The addition of 5-25% 1,2-propylene glycol decreases the pH of investigated gels from 4.00 to 4.46 (1:1) and from 3.70 to 4.33 (2:1). The use of hydroxypropylmethylcellulose allowed to obtain physiological range. The addition of hydroxypropylmethylcellulose reduces the pH and maintains high adhesion.
8
Publication available in full text mode
Content available

INFLUENCE OF POLOXAMER 407 ON THE PROPERTIES GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2016
|
vol. 21
154-159
EN
Thermosensitive hydrophilic powders passing in gels containing lactic acid complexed with chitosan at a stoichiometric ratio 1:1 and 8:1 reveal pH ranged from 4.00 to 4.91 and 2.56 to 3.42. Rheological studies demonstrated that the investigated thermosensitive gels obtained from powders have the dynamic viscosity in the ranged from 269 mPa*s to 579 mPa*s for the 1:1 stoichiometric ratio and in the range from 220 mPa*s to 530 mPa*s for 8:1 ratio. As a result of the research preparations with different pH values including the physiological range were obtained. The thermosensitive gels obtained from the thermosensitive powders were characterized by the specific dynamic viscosity. The results proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
9
Publication available in full text mode
Content available

THE USE OF DEXTRAN IN GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2017
|
vol. 22
143-150
EN
Powders for gynecological use pass under natural conditions in gels covering the vaginal mucosa. This study has shown the impact of used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. All gels with complexes in the ratios of 1:1 and 2:1 (lactic acid:chitosan) showed a pH in the physiological range 3.5-5.0 at 37°C. The addition of dextran and excipients to these complexes allows various formulations over a wide range of pH to be obtained. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and dextran in comparison to gels without dextran. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion. The presented work shows that it is possible to obtain gels with high adhesion properties to vaginal mucous membrane.
10
Publication available in full text mode
Content available

INCREASING THE EFFECTIVENESS OF CHITOSAN GELS TO PROTECT THE OESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2023
|
vol. 28
111-118
EN
The troublesome symptoms of gastro-oesophageal reflux disease are a serious health, medical, and social problem for patients. The main problem is gastro-oesophageal acid reflux. In this study, I investigated hydrogels that could prevent the destruction of the oesophageal mucosa. I investigated the effect of chitosan and poloxamer 407 on the protective properties of gels. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity. Preparations containing 25% poloxamer 407 showed the highest pH. Texture tests showed the effect of the poloxamer concentration on the adhesion performance of the tested gels. The findings suggest that the gels can be used to treat advanced acid reflux.
11
Publication available in full text mode
Content available

INFLUENCE OF CHITOSAN ON THE PROPERTIES OF GELS PROTECTING OF THE ESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2019
|
vol. 24
135 - 144
EN
Gastro-esophageal reflux is a term that defines the reverse flow of acid gastric contents into the esophagus. On the other hand, alkaline reflux occurs in the case when alkaline intestinal contents enter the esophagus. The aim of the study was to examine the pharmaceutical properties of gels for the treatment of gastro-esophageal reflux, covering the mucosa, allowing prolonged contact with the esophageal mucosa. Formulations containing the PVP K-30 showed the lowest pH, which is an important feature and can be used in the treatment of advanced alkaline reflux. Gels containing PVP K-90 and chitosan can be used in the treatment of acid reflux. The addition of chitosan significantly increased the dynamic viscosity of the tested gels. The study of the work of adhesion showed the effect of PVP K-30 and PVP K-90 and their concentration on the value of the work of adhesion. The presented studies have shown that it is possible to obtain gels with high adhesion to the esophageal mucous membrane.
12
Publication available in full text mode
Content available

INFLUENCE OF A CHOSEN AUXILIARY SUBSTANCE ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2014
|
vol. 19
87-93
EN
Hydrophilic powders passing gels containing lactic acid complexed with chitosan at a stoichiometric ratio of 1:1 and 8:1 revealed pH ranged from 3.92 to 4.44 and 2.36 to 2.84. Rheological studies demonstrated that the research gels obtained from powders possess the dynamic viscosity ranging from 53 to 398 mPa.s for the 1:1 stoichiometric ratio in the complex and from 19 to 242 mPa.s for the 8:1 ratio. As a result of the research, preparations with different pH values, including physiological range, were obtained. Powders show that the adhesion of the gel covering the surface of the apparatus simulates the conditions in the vagina. The gels obtained from the powders were characterised by the specific dynamic viscosity and possess the work of adhesion. The results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
13
Publication available in full text mode
Content available

THE EFFECT OF SELECTED POLYMERS ON THE PROPERTIES OF THERMOSENSITIVE HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2010
|
vol. 15
135 - 142
EN
Bacterial vaginitis affects women of all age groups. Numerous recurrences of the condition are widely discussed by clinicians. Traditional therapeutic schemes recommended by world treatment centres and health organizations do not bring satisfactory results. Their effects are hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. The investigations demonstrated that the thermosensitive polymer - poloxamer 407 increases significantly the adhesive properties of hydrophilic gels, but at the same time it increases their pH. The addition of PVP K-30 or hydroxypropylmethylcellulose reduces the pH and maintains high adhesion. The use of PVP K-30 and hydroxypropylmethylcellulose allowed to obtain narrow physiological range – lower limits of the physiological range. Rheological investigations revealed an increase in the dynamic viscosity of reparations containing poloxamer 407 with the addition of PVP K-30 or hydroxypropylmethylcellulose in comparison to the reference gels.
14
Publication available in full text mode
Content available

EFFECT OF A POLYVINYL ALCOHOL AND SELECTED AUXILIARY SUBSTANCES ON THE PROPERTIES OF THERMOSENSITIVE HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2013
|
vol. 18
|
issue 18
107-114
EN
Gels containing lactic acid complexed with chitosan at a stechiometric ratio 1:1 and 2:1 and 5-25% content of PEG-200 reveal pH from 3.42 to 4.95. The addition of 20 – 25% poloxamer 407 increases the pH from 4.55 to 5.30 for 1:1 gels and from 4.00 to 4.85 for 2:1 gels. The addition of 0.5% polyvinyl alcohol decreases the pH of the investigated gels from 4.00 to 4.55 for 1:1 gels and from 3.85 to 4.40 for 2:1 gels. The addition of poloxamer 407 at concentrations of 20 to 25% increases the dynamic viscosity from 506.14 to 641.20 for 1:1 and from 540.35 to 692.55 for 2:1 ratios. The addition of 0.5% polyvinyl alcohol increases the dynamic viscosity from 590.20 to 720.63 for 1:1 and from 560.90 to 698.82 for 2:1 ratios. The addition of polyvinyl alcohol and auxiliary substances reduces the pH and maintains high adhesion.
15
Publication available in full text mode
Content available

PHYSICOCHEMICAL PROPERTIES OF GELS WITH CHITOSAN THAT PROTECT THE OESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2022
|
vol. 27
175-182
EN
The incidence of reflux disease increases with age, regardless of gender. This disease is diagnosed more often in highly developed countries. In addition to acidic reflux, the discharge of alkaline intestinal contents into the oesophagus is a major problem. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and hydroxypropylmethylcellulose on the properties of chitosan-containing gels. Preparations containing 4.0% hydroxypropylmethylcellulose showed the lowest pH. These gels could be used to treat advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of the hydroxypropylmethylcellulose concentration on the adhesion work of the tested gels.
16
Publication available in full text mode
Content available

EVALUATION OF HYDROPHILIC GLOBULES WITH SODIUM ALGINATE CONTAINING A LACTIC ACID– CHITOSAN COMPLEX

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2021
|
vol. 26
170-177
EN
An important issue in the treatment of vaginitis is the amount of time the drug remains on the vaginal mucosa. If the contact time is too short, the drug cannot work effectively to ensure the correct pH in the vaginal environment. This study evaluated formulations of globules containing sodium alginate, lactic acid and chitosan with different pH and rheological properties. The experimental studies revealed that it is possible to produce a preparation with optimal pharmaceutical and application properties. The use of an appropriate ratio of lactic acid to chitosan in the complex and the appropriate concentration of sodium alginate produces a preparation with excellent properties to coat the surface of the vaginal mucosa.
17
Publication available in full text mode
Content available

EFFECT OF A HYDROPHILISING SUBSTANCE ON THE VISCOSITY OF GYNAECOLOGICAL GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2012
|
vol. 17
125 - 132
EN
Thus ensuring a continuous action of a drug also during daily activity time of a patient is a vital question in gynaecological treatment. The main problem in applied therapies is to maintain the continuity of treatment during 24 hours. The addition of 5-25% glycerol or 1,2-propylene glycol decreases the pH of investigated gels with calcium alginate to 4.20 to 4.88 (1:1) and 3.69 to 4.19 (2:1); 4.29 to 4.88 (1:1) and 3.62 to 4.40 (2:1). The addition of 5-25% glycerol or 1,2-propylene glycol increases the dynamic viscosity gels with calcium alginate from 595.14 to 820.25 for 1:1 and 640.15 to 769.12 for 2:1; 585.40 to 815.56 for 1:1 and 648.52 to 780.10 for 2:1 ratios. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing poloxamer 407 with the addition of calcium alginate and glycerol or 1,2-propylene glycol in comparison to the reference gels.
18
Publication available in full text mode
Content available

PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH SODIUM ALGINATE CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

100%
Małolepsza-Jarmołowska K.
|
|
vol. 23
130 - 139
EN
The insufficient duration of the drug’s contact with the vaginal mucosa does not provide adequate pH, conditioning the physiological biocenosis of the organ. This effect is hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. This study has shown the impact of the used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. The addition of sodium alginate and excipients to these complexes allows various formulations to be obtained over a wide range of pH. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and sodium alginate in comparison to gels without sodium alginate. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion.
19
Publication available in full text mode
Content available

THE PROPERTIES OF THERMOSENSITIVE GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2015
|
vol. 20
183-194
EN
The investigations showed that the addition of a 20%, 23% and 25% poloxamer 407 increases the adhesive properties of the investigated powders, but at the same time it increases their pH. The enrichment of the composition of the tested powders containing 5% glycerol and 5% 1,2-propylene glycol resulted in increased pH of the formulations. A modification of the composition of the tested powders containing 5% glycerol and 5% 1,2-propylene glycol has increased the range of the dynamic viscosity of formulations. The enrichment of the composition of the tested powders containing 5% hydroxypropylmethylcellulose resulted in increased the range of the dynamic viscosity and decreased pH of the formulations. Laboratory tests have shown that it is possible to obtain thermosensitive gels with high adhesion properties to vaginal mucous membrane.
20
Publication available in full text mode
Content available

ASSESSMENT OF PHARMACEUTICAL PROPERTIES OF THERMOSENSITIVE GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2016
|
vol. 21
160-164
EN
pH of gels ranged from 3.92 to 4.44 for gels 1:1 and from 2.36 to 2.84 for 8:1 ratio. The addition of 20%, 23% or 25% poloxamer 407 increases the pH ranged from 4.00 to 4.91 for gels with 1:1 ratio and from 2.56 to 3.42 for 8:1 ratio. Rheological studies demonstrated that the investigated gels obtained from powders have the dynamic viscosity ranged from 53 mPa*s to 398 mPa*s for the 1:1 stoichiometric ratio in the complex and from 19 mPa*s to 242 mPa*s for 8:1 ratio. The addition of calcium alginate with polyoxyethylene glycol-200 reduces the pH and maintains high dynamic viscosity. The thermosensitive gels obtained from thermosensitive powders shows high adhesion and are difficult to separate from the probe.
first rewind previous Page / 2 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.