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Severe Course of Crohn's Disease Complicated with Multiple Peristomal Fistulas

100%
Banaszkiewicz Z., Kłopocka M., Jawień A.
Polish Journal of Surgery
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2009
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vol. 81
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issue 4
198-202
EN
To date healthy male, 51, was admitted to hospital for abdominal pain and body weight loss of 10 kilograms within 6 weeks. Soon after admittance the patient's condition deteriorated and he was operated on for ileus. The Hartman's resection of sigmoid colon was the option for obstructive tumour. First signs of stoma complications were being reported from day 16 on and soon overt multiple fistula formation was diagnosed. Systemic and site treatment was involved (5-ASA, steroids). Nevertheless, the patient's condition was not improving within following 8 months, which led to succeeding hospitalisations, finally, infliximab therapy was the successful one. On patient's demand the hind-gut reconstruction was performed. Partial resection of involved bowel and stoma followed by end-to-end hind-gut reconstruction was the option. Up to now (i.e. 8 months after the reconstruction) the patient remains in good condition.
2
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Background level of 8-oxo-2'-deoxyguanosine in lymphocyte DNA does not correlate with the concentration of antioxidant vitamins in blood plasma.

100%
Gackowski D., Ciecierski M., Jawień A., Oliński R.
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2001
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vol. 48
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issue 2
535-539
EN
Antioxidant vitamins, being effective free radical scavengers, can protect cellular DNA from oxidative damage. Therefore, in the present study we report on the relationship between basal level of 8-oxo-2'-deoxyguanosine in human lymphocyte DNA and the concentration of antioxidant vitamins (A, C and E). The average level of 8-oxo-2'-deoxyguanosine in lymphocytes of the studied group (15 males and 20 females) was 9.57 per 106 dG molecules. The endogenous level of ascorbic acid (vitamin C) in the plasma was, on average, 56.78 μM, while the mean concentrations of retinol (vitamin A) and α-tocopherol (vitamin E) were 1.24 μM and 25.74 μM, respectively. No correlations were found between individual 8-oxo-2'-deoxyguanosine levels in lymphocyte DNA and endogenous concentration of the vitamins.
3
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Evaluation of the Dependency Between the Claudication Distance Reported by the Patient and the Ankle-Brachial Index at Rest, and the Distance Covered on the Treadmill Test in Patients with Lower Limb Ischemia

88%
Grzela T., Migdalski A., Jawień A., Piotrowicz R., Szotkiewicz A.
Polish Journal of Surgery
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2008
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vol. 80
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issue 4
184-189
EN
Views concerning the dependency between the claudication distance and ankle-brachial index values are ambiguous.The aim of the study was to determine the correlation between the distance covered during the treadmill test and ankle-brachial index, and the distance covered during the treadmill test and claudication distance reported by the patient.Material and method. The study group contained 75 patients of both genders, above the age of 40 years, treated at the Vascular Disease Outpatient Clinic, diagnosed with one or both-sided intermittent claudication, and with an ankle-brachial index below 0.9. In all patients we evaluated the ankle-brachial index at rest, considering both lower limbs, as well as the claudication distance on the treadmill test (3.2 km/h, 12° gradient). We determined the distance traveled until the manifestation of pain (distance free of pain), and the distance until complete stop (total walking distance). Analysis always considered one (the worse) lower limb of the patient.Results. There was no correlation between the ankle-brachial index and distance covered during the treadmill test. However, there was a statistically significant dependency between the claudication distance reported by the patient, and that observed during the treadmill test. A moderate correlation was observed between the total walking distance and the claudication distance reported by the patient (r= 0.441, p=0.001).Conclusions. 1. The ankle-brachial index at rest should not be used as a measure of the intensification of lower limb ischemia symptoms in patients with intermittent claudication. 2. The claudication distance reported by the patient only moderately correlates with the total observed walking distance.
4
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Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer

88%
Linkowska K., Jawień A., Marszałek A., Skonieczna K., Grzybowski T.
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2015
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vol. 62
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issue 3
625-627
EN
Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome. Recent studies demonstrated an association of CAG repeat polymorphism in the second exon of POLG gene with the risk of cancer. We investigated the CAG repeat variability in the POLG gene in tumor and non-tumor tissues from colorectal cancer patients and in DNA samples isolated from blood obtained from age-matched healthy persons. Somatically occuring CAG-repeat alterations in cancer tissues have been observed in 10% of patients, but no association has been found between the CAG repeat variants in the POLG gene and colorectal cancer risk.
5
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Usefulness of CEA Concentration Measurement and Classic Colonoscopy in Follow-Up After Radical Treatment of Colorectal Cancer

76%
Banaszkiewicz Z., Jarmocik P., Frasz J., Tojek K., Mrozowski M., Jawień A.
Polish Journal of Surgery
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2011
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vol. 83
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issue 6
310-318
EN
There is always a certain rate of recurrence after radical treatment for cancer and to get on it an early detection of disease set back is crucial.Material and methods. Medical data of patients operated on for primarily detected colorectal cancer in years 1993-2002 was retrospectively reviewed. Usefulness of follow-up means such as physical examination, or CEA and endoscopic surveillance was analyzed. All mentioned above were applied to scheduled follow-up (in 3, 6 and 12 month intervals following an operation and annually after that by the year 5).Results. Complete and reliable data was obtained from 340 out of 502 follow-up intended subjects (67.7%). Elevated CEA was the most frequent predictor of recurrence within non-symptomatic subjects meeting follow-up appointments (60%). The cancer set back diagnosed by means of either physical or endoscopic examinations was the case only in one out of five patients (20.75% and 18.87% respectively). Clinical onset of recurrence making patients meet an unscheduled appointment was found increasing relative risk of nothing-but-palliative option either for them with local set back, or meta-static spread. Relative risk of onset of meta-chronous colonic cancer was significantly higher in patients being affected by synchronous advanced adenoma at time of surgery compared to those with one-fold changes.Conclusions. CEA scheduled follow-up after treatment for colorectal cancer CRC seems adequate to provide a good outcome of treatment for recurrent tumors. CRC patients presenting with synchronous advanced adenomas at time of surgery are probably to be under more intensive endoscopic surveillance.
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