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Triterpene sapogenins with oleanene skeleton: chemotypes and biological activities

100%

Jatczak K., Grynkiewicz G.

2014

vol. 61

issue 2

227-243

Critical survey of a selected class of pentacyclic triterpenes - the oleanane family, is presented based on current literature in order to underline their value for medicinal chemistry and drug development potential. Oleanenes may be considered as a renewable resource of valuable research materials which are structurally diverse, inherently biocompatible and have built-in affinity for many categories of functional proteins. Although availability of particular compounds from natural sources may be very low, synthetic methods elaborated by generations of chemists, secure a way to obtaining desirable structures from commercial starting materials.

Preparation of selectively protected protoescigenin derivatives for synthesis of escin analogs and neoglycoconjugates

71%

Jatczak K., Gruza M., Filip K., Cmoch P., Grynkiewicz G.

Open Chemistry

2014

vol. 12

issue 12

1222-1231

Protoescigenin, the main aglycone of horse chestnut saponin mixture known as escin, was selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene.

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1 Acta Biochimica Polonica

1 Open Chemistry

2 2014

2 Grynkiewicz G.

2 Jatczak K.

1 Cmoch P.

1 Filip K.

1 Gruza M.

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Triterpene sapogenins with oleanene skeleton: chemotypes and biological activities

Preparation of selectively protected protoescigenin derivatives for synthesis of escin analogs and neoglycoconjugates