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1
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Ochrona enzymatyczna błon erytrocytarnych przed wolnymi rodnikami

100%
Jóźwiak Z.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
|
1985
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vol. 3
2
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Effect of gamma-irradiation on energetic metabolism of porcine blood lymphocytes, platelets and erythrocytes

63%
Jóźwiak Z., Leyko W., University of Łódź I. o. B. a. B.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1981
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vol. 1
PL
Praca dotyczy wpływu promieniowania gamma w zakresie dawek 0,5-500 krad na zawartość AMP, ADP i ATP erytrocytów, limfocytów i płytek krwi wieprzowej. Stosowane promieniowanie gamma we wszystkich 3 przypadkach wywołuje ten sam charakter zmian w zawartości nukleotydów adehinowych. Zależność zawartości nukleotydów od dawki promieniowania w zakresie 0,5-7 krad uzyskana eksperymentalnie jest wysoce zgodna z zastosowanymi obliczeniami matematycznymi. W oparciu o otrzymane wyniki sugeruje się, że popromienne zmiany zawartości nukleotydów adeninowych ' związane są z uszkodzeniami błon komórkowych.
3
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Poly-(ethylene glycol) protects erythrocytes against thermal hemolysis

63%
Pałecz D., Jóźwiak Z., University of Łódź D. o. T.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1994
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vol. 10
PL
W artykule badano wpływ polietylenoglikolu na termostabilność erytrocytów.
4
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Changes in GSH-antioxidant system induced by daunorubicin in human normal and diabetic fibroblasts.

51%
Zatorska A., Maszewski J., Jóźwiak Z.
Acta Biochimica Polonica
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2003
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vol. 50
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issue 3
825-835
EN
We investigated the effect of daunorubicin on glutathione content and activity of GSH-related enzymes in cultured normal and diabetic human fibroblasts. Cells were incubated with 4 μM daunorubicin (DNR) for 2 h followed by culture in drug-free medium for up to 72 h. Treatment of diabetic cells with the drug caused a time-dependent depletion of intracellular GSH and a decrease of the GSH to total glutathione ratio. GSH depletion was accompanied by apoptotic changes in morphology of the nucleus. Analysis of GSH-related enzymes showed a significant increase of the activities of Se-dependent and Se-independent peroxidases and glutathione S-transferase. In contrast, glutathione reductase activity was reduced by 50%. Significant differences between normal and diabetic cells exposed to DNR were observed in the level of GST and Se-dependent glutathione peroxidase activities. These findings indicated that daunorubicin efficiently affects the GSH antioxidant defense system both in normal and diabetic fibroblasts leading to disturbances in glutathione content as well as in the activity of GSH-related enzymes.
5
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The influence of alloxan on erythrocyte membrane proteins

51%
Jóźwiak Z., Stephan R., Bosse H., Gärtner H., Zofia Jóźwiak - University of Łódź C. o. B., Roland Stephan - Gesamthochschule Kassel E. I. F. P., Harald Bosse - Gesamthochschule Kassel E. I. F. P., Helmut Gärtner - Gesamthochschule Kassel E. I. F. P.
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
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1991
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vol. 8
PL
Metodą ESR badano oddziaływanie alloksanu na wyizolowane błony erytrocytów w zakresie temperatur 10-50°C. Wyniki wskazują, że błony po inkubacji z alloksanem są mniej wrażliwe na działanie temperatury aniżeli preparaty kontrolne.
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