Search results

Sort By:

Limit search:

Granules of human neutrophils

100%

Wysocka J., Lipartowska R., Lipska A.

vol. 55

issue 1

177-188

The exocytosis of cytoplasmic granules plays a most important role in the regulation of many neutrophils functions: adhesion, phagocytosis, killing of bacteria and interaction with endothelial cells. Neutrophils contain following types of granules: azurophilic (primary) granules, specific (secondary) granules, gelatinase-rich tertiary granules and secretory vesicles. Neutrophil granules may be classified on the basis of their size, morphology, density or with reference to a given protein.

Selection for body weight induces differences in exploratory behavior and learning in mice

100%

Wirth-Dzieciolowska E., Lipska A., Wesierska M.

Acta Neurobiologiae Experimentalis

2005

vol. 65

issue 3

243-253

Mice that were selected for over 108 generations for body weight at the postnatal (PN) day 21 were examined in the open field (OF) test and in the Lashley maze (LM) for their exploratory behavior and spatial learning. Light (L), heavy (C) and control (K) lines of mice in three age groups: PN-21, PN-56 and PN-90, were tested once in the OF and three times in the LM. During the session in the OF the L mice displayed a steady increase of behavioral activity (sum of locomotion and rearing, climbing, sniffing, and grooming acts), whereas mice C and K habituated in the last stage. During entire session in the OF activity of the L mice was lower than that of the C and K mice. The L mice displayed high defecation/urination scores. In the learning task the L mice performed worse than the C and K mice. In conclusion, behavior of the L line was different from that of the two other lines: they showed higher anxiety and poorer spatial learning.

Evaluation of selected peripheral blood leukocyte functions in patients with various forms of periodontal disease

76%

Pietruska M., Zak J., Wysocka J., Jaworowska B., Zelazowska B., Lipska A., Stokowska W.

Archivum Immunologiae et Therapiae Experimentalis

2004

vol. 52

issue 3

208-212

Periodontitis (P) is an infectious disease that develops in the supporting tissues of the tooth. One of the risk factors leading to it may be dysfunction of some immune system cells. Therefore, the object of the study was to assess selected functions of peripheral blood leukocytes in patients with various forms of P. As leukocytes are able to secrete interleukin (IL)-4 and IL-6, concentrations of their soluble receptors and the expression of their membrane receptors were investigated. Twenty generally healthy subjects with agressive (AP) and chronic periodontitis (CP) were enrolled in the study. The control group consisted of 8 healthy subjects, with no changes in periodontium. Peripheral blood mononuclear cells (PBMCs) were isolated and cultured. Levels of IL-4, IL-6, and their soluble receptors sIL-4R and sIL-6R were determined in the supernatant by ELISA. The expressions of cell surface IL-4R and IL-6R were assayed on PBMC using flow cytometry. No statistically significant differences were found in the selected parameters between people with periodontal disease and healthy controls. However, in subjects with AP, there was an increasing tendency in IL-6 concentration and IL-4R expression on PBMCs. Our results show that leukocytes play a significant part in P and their activity is probably lesion-dependent. Estimation of the cytokines secreted by leukocytes may facilitate differentiation and prognosis of the disease progression.

Refine search results

1 Acta Neurobiologiae Experimentalis

1 Archivum Immunologiae et Therapiae Experimentalis

1 Postępy Higieny i Medycyny Doświadczalnej

1 2005

1 2004

1 2001

3 Lipska A.

2 Wysocka J.

1 Jaworowska B.

1 Lipartowska R.

1 Pietruska M.

1 Stokowska W.

1 Wesierska M.

1 Wirth-Dzieciolowska E.

1 Zak J.

1 Zelazowska B.

Search results

Granules of human neutrophils

Selection for body weight induces differences in exploratory behavior and learning in mice

Evaluation of selected peripheral blood leukocyte functions in patients with various forms of periodontal disease