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1

Molecular mimicry of bacterial polysaccharides and their role in etiology of infectious and autoimmunological diseases

100%
Korzeniowska-Kowal A., Witkowska D., Gamian A. S.
Postępy Higieny i Medycyny Doświadczalnej
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2001
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vol. 55
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issue 2
211-232
EN
Molecular mimicry is one of the most important pathogenic factor of microorganism and is defined as a structural similarity of microbial molecules to host tissue contributing to the pathogenicity. Mimicry can be observed at the molecular, serological and functional level. In the review the infectious diseases have been discussed where the mimicry phenomenon may occurr, and also autoimmune disease where due to the molecular mimicry bacterial structures are potent to induce adverse immune reactions. The cross-reacting molecules mimicking the host structures comprise colominic acid, sialic acid containing capsular polysaccharides of Streptococcus group B, phosphocholine containing antigen, lipopolysaccharides of Campylobacter jejuni contributing in induction of Guillain-Barre syndrome or Lewis antigen containing lipopolysaccharides of Helicobacter pylori inducing gut carcinoma. Knowledge on the phenomenon of molecular mimicry is important when new conjugate vaccine has to be constructed, because great care should be paid not to induce autoantibodies with synthetic immunogen. Investigation of microbial factors reveal that many autoimmune diseases are of infection etiology.
2

Immunochemical studies of the lipopolysaccharides of Hafnia alvei PCM 1219 and other strains with the O-antigens containing D-glucose 1-phosphate and 2-deoxy-2-[(R)-3-hydroxybutyramido]-D-glucose

64%
Katzenellenbogen E., Kocharova N. A., Korzeniowska-Kowal A., Gamian A., Bogulska M., Szostko B., Shashkov A. S., Knirel Y. A.
Archivum Immunologiae et Therapiae Experimentalis
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2008
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vol. 56
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issue 5
347-352
EN
Introduction: Hafnia alvei is the only species of the genus Hafnia, which belongs to the family of Enterobacteriaceae. These Gram-negative bacteria are commonly distributed in the natural environment and are often the cause of human opportunistic infections. Their lipopolysaccharides (LPSs) are important surface antigens which are responsible for the serological specificity and numerous cross-reactions with other enterobacterial genera. So far, 29 different O-polysaccharide (OPS, O-antigen) structures in Hafnia LPSs have been established and for some of them the molecular basis of the serological activity has been elucidated. Materials and Methods: OPS from H. alvei strain PCM 1219 was obtained by mild acid hydrolysis of the LPS followed by gel permeation chromatography of carbohydrate material on Sephadex G-50 column. The polysaccharide structure was determined using chemical methods as well as 13C NMR and 1H NMR spectroscopy. For serological studies, SDS-PAGE, immunoblotting, and passive hemagglutination tests were used. Results: The serological studies revealed a cross-reactivity of the LPSs of H. alvei PCM 1219 and a group of H. alvei strains with an O-antigen containing D-glucose 1-phosphate and [(R)-3-hydroxybutyramido]-D-glucose. The following structure of the OPS was established: 2)-alpha-d-Glcp-(1-PO4-6)-alpha-d-GlcpNAcyl-(14)-alpha-d-GalpNAc-(13)-beta-d-GalpNAc-(1- > 3---- OAc6<-1 alpga-d-Glcp where Acyl stands for (R)-3-hydroxybutyryl and the degree of O-acetylation is 70%. The structure of the core oligosaccharide was found to be typical of the genus Hafnia. Conclusions: Based on the OPS structure and serological results it was concluded that H. alvei strain PCM 1219 should be classified in the same serogroup as the H. alvei type strain ATCC 13337 and five other strains containing D-glucose 1-phosphate and 2-deoxy-2-[(R)-3-hydroxybutyramido]-D-glucose in their O-antigens.
3
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Nasal carriage of various staphylococcal species in small ruminant lentivirus-infected asymptomatic goats

46%
Moroz A., Szaluś-Jordanow O., Czopowicz M., Brodzik K., Petroniec V., Augustynowicz-Kopeć E., Lutyńska A., Roszczynko M., Gołoś-Wójcicka A., Korzeniowska-Kowal A., Gamian A., Mickiewicz M., Frymus T., Petelicka H., Kaba J., Moroz A., Szaluś-Jordanow O., Czopowicz M., Brodzik K., Petroniec V., Augustynowicz-Kopeć E., Lutyńska A., Roszczynko M., Gołoś-Wójcicka A., Korzeniowska-Kowal A., Gamian A., Mickiewicz M., Frymus T., Petelicka H., Kaba J.
Polish Journal of Veterinary Sciences
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2020
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vol. 23
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issue 2
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