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Comparison of Iron Oxide-Related MRI Artifacts in Healthy and Neuropathological Human Brain Tissue

100%

Masarova M., Krafcik A., Teplan M., Strbak O., Gogola D., Boruta P., Dobrota D., Frollo I.

Acta Physica Polonica A

2017

vol. 131

issue 4

1108-1110

The aim of this study is to clarify whether clinical magnetic resonance imaging data can be utilised to evaluate the pathological processes associated with disrupted iron homeostasis, such as neurodegenerative processes or cirrhosis. Although MRI has the potential to become a non-invasive biomarker of such pathology, new quantification methods must be introduced. Our findings confirmed that it is possible to detect significant difference between healthy and pathological tissue from standard T2 weighted MRI protocols.

Differentiation of Native and Reconstructed Ferritin using the MRI Gradient Echo Pulse Sequence

100%

Balejcikova L., Strbak O., Baciak L., Kovac J., Masarova M., Krafcik A., Kopcansky P., Dobrota D., Frollo I.

Acta Physica Polonica A

2017

vol. 131

issue 4

1093-1095

Ferritin is a biological iron storage biomacromolecule, consisting of a spherical protein shell (apoferritin) and mineral iron core. It plays a crucial role in the pathological processes of disrupted iron homeostasis followed by iron accumulation, linked with various disorders (e.g. neuroinflammation, neurodegeneration, cirrhosis, cancer, etc.) In vitro reconstructed ferritin, with the assistance of a non-invasive magnetic resonance imaging technique, has the potential to become a suitable biomarker of these pathological processes. Through gradient echo pulse sequencing, we were able to clearly distinguish between native (physiological) and reconstructed/iron-overloaded (pathological) ferritin, which can serve as a starting point for the development of a method for their differentiation. Such method is necessary for the early diagnosis of iron-based diseases.

Effect of BSA Protein on the Contrast Properties of Magnetite Nanoparticles during MRI

81%

Strbak O., Kubovcikova M., Baciak L., Khmara I., Gogola D., Koneracka M., Zavisova V., Antal I., Masarova M., Krafcik A., Kopcansky P., Dobrota D., Frollo I.

Acta Physica Polonica A

2017

vol. 131

issue 4

1102-1104

The aim of the study was to establish whether there is a significant change in the MRI contrast of magnetite nanoparticles, after BSA protein binding on the surface of particles. The rationale is the applicability of this feature in clinical practice for the tracking of specific proteins which are often associated with various pathologies. Contrast agents could bind to this specific marker, with the change in MRI contrast indicating the presence of pathology. We found that changes in relative contrast acquired at low-field MRI offer potential for the differentiation of magnetite nanoparticles with and without BSA protein. However, the variations in the transverse relaxation time (T₂) and transverse relaxivity (r₂), acquired at high-field MRI, were too small to be applicable for biomedical applications.

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3 Acta Physica Polonica A

3 2017

3 Dobrota D.

3 Frollo I.

3 Krafcik A.

3 Masarova M.

3 Strbak O.

2 Baciak L.

2 Gogola D.

2 Kopcansky P.

1 Antal I.

1 Balejcikova L.

1 Boruta P.

1 Khmara I.

1 Koneracka M.

1 Kovac J.

1 Kubovcikova M.

1 Teplan M.

1 Zavisova V.

Search results

Comparison of Iron Oxide-Related MRI Artifacts in Healthy and Neuropathological Human Brain Tissue

Differentiation of Native and Reconstructed Ferritin using the MRI Gradient Echo Pulse Sequence

Effect of BSA Protein on the Contrast Properties of Magnetite Nanoparticles during MRI