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Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage

100%

Biskup E., Gołębiowski M., Gniadecki R., Stepnowski P., Łojkowska E.

2012

vol. 59

issue 2

255-260

Rhaponticum carthamoides plants ("maral root") are widely used in Siberian folk medicine. The present study reports for the first time the presence of pentacyclic terpenoid, α-amyrin, in methanol extract from leaves of this plant. α-Amyrin induced proliferation of human keratinocytes (HaCaT) by about 18% while other extract components were ineffective. A panel of biochemical and cell-based assays testing the antioxidative and cytoprotective activites of α-amyrin indicated no antioxidative activity of this compound. α-Amyrin did not protect HaCaT cells against the damage caused by UVB radiation.

Application of BDD thin film electrode for electrochemical decomposition of heterogeneous aromatic compounds

86%

Czupryniak J., Fabiańska A., Stepnowski P., Ossowski T., Bogdanowicz R., Gnyba M., Siedlecka E.

The aim of the presented study is to investigate the applicability of electrochemical oxidation of aromatic compounds containing heteroatoms, e.g. waste from production of pesticides or pharmaceutics, at a borondoped diamond (BDD) electrode. The BDD electrodes were synthesized by microwave plasma enhanced chemical vapour deposition (MW PE CVD). Investigation of the electrode surface by optical microscopy and scanning electron microscopy (SEM) confirmed that the synthesized layer was continuous and formed a densely packed grain structure with an average roughness of less than 0:5 μm. The influence of important electrochemical parameters: current density, kind of reactor, pH or mixing operation, on the efficiency of the oxidation was investigated. The fouling of electrode’s surface caused by the deposition of organic material was observed during CV and galvanostatic experiments. At low current density the oxidation rate constant k was low, but the current efficiency was relatively high. The BDD can be used successfully to remove heterogeneous aromatic compounds existing either as molecules or cations. During 4 h of electrolysis 95% of aromatic compounds were electrochemically decomposed to mineral forms. It was observed that the influence of the initial pH on mineralization was marginal.

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1 Acta Biochimica Polonica

1 Open Physics

2 2012

2 Stepnowski P.

1 Biskup E.

1 Bogdanowicz R.

1 Czupryniak J.

1 Fabiańska A.

1 Gniadecki R.

1 Gnyba M.

1 Gołębiowski M.

1 Ossowski T.

1 Siedlecka E.

1 Łojkowska E.

Search results

Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage

Application of BDD thin film electrode for electrochemical decomposition of heterogeneous aromatic compounds