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Multilevel regulation of the tyrosine hydroxylase. I.Posttranscriptional levels

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Lenartowski R., Goc A.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
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vol. 56
|
issue 4
555-565
EN
The tyrosine hydroxylase plays a key role in the catecholamine synthesis responding to many stimuli disturbing homeostasis. In this part we described the posttranscriptional levels of the gene and the protein regulation including: alternative splicing, isoform specificity, feedback inhibition, protein phosphorylation and dephosphorylation, protein stability, translational regulation.
2

Multilevel regulation of the tyrosine hydroxylase. II. Transcriptional regulation

100%
Lenartowski R., Goc A.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
|
vol. 56
|
issue 5
671-686
EN
The tyrosine hydroxylase gene is subject to very precise regulation which aim is to adjust the level of the catecholamines to current stimuli disturbing the homeostasis . The fine tuning of the TH gene activity is realized by the ?cross-talk? between the complexes of transcriptional factors with their appropriate regulatory sequences. The transcriptional aspect of that regulation has been reviewed emphasizing the rule of the regulatory sequences in determining cell, tissue and developmental specificity of the TH gene activity.
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