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Ocena działania masażu gastrycznego brzucha u chorych z zaparciem objętych stacjonarną opieką paliatywną – badanie pilotażowe

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Dadura E., Stępień P., Iwańska D., Wójcik A.
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2018
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vol. 31
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issue 4
19-34
EN
Introduction The problem of constipation in Poland concerns 13.4% of the healthy population. In the case of patients treated with opioids, this number increases to 70-90%, which constitutes a serious problem that lowers the patients' quality of life. The aim of the study was to assess the effects of abdominal massage, which successfully reduces constipation in various diseases, on palliative care patients. Material and methods The research included 18 patients of a palliative care facility (mean age 78.3 ± 10 years), 11 of whom completed the study. The study participants were randomly divided into two groups, i.e. a pilot group (abdominal massage and kinesiotherapy) and a control group (kinesiotherapy). The therapy lasted 8 weeks and blind evaluation was carried out once per week. The study involved evaluating constipation intensity (The Bowel Function Index), the frequency of defecation (medical documentation) and abdomen circumference (anthropometric tape). The collected data were analysed statistically with the use of Statistica software. Results The observed differences between the studied groups undergoing different therapies in subsequent weeks were not statistically significant. However, in the group in which abdominal massage was implemented, a decrease in the intensity of constipation, an increase in the frequency of defecation and a reduction in abdomen circumference were noted compared to the control group. The patients also indicated additional positive effects of this form of therapy, i.e. an improvement in breathing, easier urination, release of excessive gas and abdominal pain reduction. Conclusions The collected data led to the conclusion that abdominal massage may result in a decrease in disorders accompanying opioid-induced constipation. Therefore, it is worth considering the implementation of this form of therapy in the case of patients in an advanced stage of cancer. There is also a need for further research in this field which will include a larger number of patients.
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The MAS NMR study of solid solutions based on the YAG crystal

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Padlyak B. V., Sergeev N. A., Olszewski M., Stępień P.
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issue 3
417-421
EN
An 27Al magic angle spinning (MAS) nuclear magnetic resonance (NMR) study of nominally pure and Cr-doped yttrium-aluminum garnet (Y3Al5O12 and Y3Al5O12:Cr) crystals is reported. It has been shown that the doping by Cr of the Y3Al5O12 crystals leads to the variation of the occupation by Al atoms both octahedrally and tetrahedrally coordinated sites of the garnet lattice.
3
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TIME MOTION DIFFERENCES BETWEEN ROMANIAN AND POLISH HIGH LEVEL YOUNG SOCCER PLAYERS DURING 6 VS. 6 SMALL SIDED GAMES AS AN EFFECT OF TRAINING PROGRAM

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Jastrzębski Z., Radzimiński Ł., Stefaniak A., Dragos P., Dumitrescu G., Stępień P., Mrozik Ł.
Central European Journal of Sport Sciences and Medicine
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2015
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vol. 10
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issue 2
55-61
EN
The purpose of this study was to present a time motion differences between Romanian and Polish young soccer players during 6 vs 6 small sided games. Young male football players from Schools of Sports Masters in Oradea (Romania) and Łódź (Poland) participated in the study. During the training session the players participated in four small-sided games 6 vs. 6 with goalkeepers (4 × 4 min, 3 min of active recovery). Heart rate responses and distance covered during small-sided games were compared. There were significant differences in the distance covered by both nationality players and age groups in reference to each intensity zone. Polish players coverd significantly longer distance compared with romanian soccer players. The results of motion abilities of young players from two countries with different training systems show that training programs can have a significant effect on adoptive abilities of the players.
4
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Human SUV3 helicase regulates growth rate of the HeLa cells and can localize in the nucleoli

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Szewczyk M., Fedoryszak-Kuśka N., Tkaczuk K., Dobrucki J., Waligórska A., Stępień P.
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2017
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vol. 64
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issue 1
177-181
EN
The human SUV3 helicase (SUV3, hSUV3, SUPV3L1) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome with exonuclease PNP (polynucleotide phosphorylase). Association of this complex with the polyA polymerase can modulate mitochondrial polyA tails. Silencing of the SUV3 gene was shown to inhibit the cell cycle and to induce apoptosis in human cell lines. However, since small amounts of the SUV3 helicase were found in the cell nuclei, it was not clear whether the observed phenotypes of SUV3 depletion were of mitochondrial or nuclear origin. In order to answer this question we have designed gene constructs able to inhibit the SUV3 activity exclusively in the cell nuclei. The results indicate that the observed growth rate impairment upon SUV3 depletion is due to its nuclear function(s). Unexpectedly, overexpression of the nuclear-targeted wild-type copies of the SUV3 gene resulted in a higher growth rate. In addition, we demonstrate that the SUV3 helicase can be found in the HeLa cell nucleoli, but it is not detectable in the DNA-repair foci. Our results indicate that the nucleolar-associated human SUV3 protein is an important factor in regulation of the cell cycle.
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