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1
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Gene expression in learning processes

100%
Kaczmarek L.
|
EN
It has repeatedly been shown that long-term memory formation involves neuronal gene expression. In this article several different roles for neuronal gene function in a context of learning are considered: maintenance of neural functioning, replenishment of cellular elements that are exhausted in response to massive neuronal stimulation accompanying behavioral training, maintenance of the plastically reorganized neuronal connections, and finally integration of information at the level of transcription factor-promoter interaction. It is strongly advocated that only careful scrutiny of learning-related gene expression phenomena may aid in understanding of the complex learning process.
2

Antisense oligonucleotides as a tool to study gene expression in the brain

63%
Szklarczyk A., Kaczmarek L.
Biotechnologia
|
1995
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issue 1
65-73
EN
Antisense oligonucleotides (asODN) have recently been used to block specific gene expression in the rodent brain.Their target include subunits of receptors for neurotransmitters, neuropeptides and transcription factors, i.e., those proteins,whose other blocker are not known.Succesful applications of the as ODN require good understanding of their pharmacokinetics, mechanisms of action and side effects in the brain.Unfortunately, very little is known in this regard.Both intraventricular and intrastructure route of administration of phosphorodiester (0-ODN) and phosphorothioate (S-ODN) ODN to the brain were effectvely employed.However doses used,even in the case of the same analog, differ up to two orders of magnitude.Since translation arrest is belived to be an effective mechanism of ODN activity in the brain, most of the authors target the ODN to the mRNA region including the translation codon, but there are most no studies of the target mRNA levels.The paper reviews the recent development in this field, offering critical evaluation of the data.
3
Content available remote

Inducible cAMP early repressor (ICER) isoforms and neuronal apoptosis in cortical in vitro culture

63%
Klejman A., Kaczmarek L.
Acta Neurobiologiae Experimentalis
|
2006
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vol. 66
|
issue 4
267-272
EN
CREB activation and CREB-dependent signaling pathways are crucial for neuronal survival. The term ICER (inducible cAMP early repressor) refers to four protein isoforms that are all endogenous, inducible antagonists of CREB. Jaworski and others (2003) have previously shown that one of those isoforms, ICER II, is highly expressed in apoptotic neurons in vitro and its overexpression evokes neuronal death. In this study we investigated the role of all four ICER isoforms in cortical neuronal culture, comparing their expression level in serum-deprived/MK-801-treated neurons and their pro-apoptotic properties towards transfected cortical neurons. We have found that all four isoforms are induced upon pro-apoptotic treatment, and also that each of them separately evokes neuronal cell death following cortical culture transfection with the genes. The most efficiently induced, as well as the most effective in evoking neuronal cell death, were both ICER Igamma and IIgamma isoforms.
4

Gene expression in neuronal apoptosis-looking far a therapeutic window

51%
Figiel I., Filipkowski R. K., Hetman M. K. B., Kaczmarek L.
Biotechnologia
|
1996
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issue 4
132-140
EN
Wxititixicity - cell loss occurring after an excessive stimulation with excitatory amino acid - has been suggested to underlie major neurodegenerative disorders.Recent studies imply that this phenomenon may have an apoptotic character, i.e.., it may be an active process.In our studies, revived herein, we confirmed and extended this view by demonstratijng a gene expression component in the processes of neuronal cell loss in three different experimental models: i. kinate administration, II, high-dose MK-801 treatment, iii.glutamate stimulation of dentate gyrus neurons cultured in vitro.In conclusion we suggest that these data, as well as tha results of a number of other studies offer a hope that there ia a therapeutic window for the treatment of a neurodegenerative diseases, both in respect to time between the insult and cell death, and through possible common mechanisms to be targeted by future therapies.One can even speculate that such therapies might aim at transcription factors, e.g. AP-1 of a specific composition and/or executor hydrolytic enzymes, e.g., cathepsin D.
5
Content available remote

Seizures-evoked activation of transcription factors

51%
Kaminska B., Lukasiuk K., Kaczmarek L.
Acta Neurobiologiae Experimentalis
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1994
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vol. 54
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issue 2
65-72
6
Publication available in full text mode
Content available

The Study of Selected Properties of Ti EB PVD Coating Deposited Onto Inner Tube Surface at Low Temperature

45%
Kottfer D., Ferdinandy M., Kaczmarek L., Trebuňa P., Hvizdoš P.
Archives of Metallurgy and Materials
|
2016
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issue 1
7
Content available remote

Nonverbal deficits in explicit and implicit memory of Parkinson's disease patients

39%
Gawrys L., Szatkowska I., Jamrozik Z., Janik P., Friedman A., Kaczmarek L.
Acta Neurobiologiae Experimentalis
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2008
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vol. 68
|
issue 1
58-72
EN
This study examined verbal and nonverbal aspects of explicit and implicit memory in a sample of 19 Parkinson's disease (PD) patients and 21 control subjects. For implicit memory evaluation, we used a Mirror Reading (MR) task employing verbal material as well as a nonverbal Serial Reaction Time (SRT) task. For explicit memory measurement we applied a word pairs task (verbal) and pairs of a Japanese ideograms task (nonverbal). The PD patients displayed impairments in the nonverbal tasks only, namely, in the SRT task and the pairs of Japanese ideograms task. No correlation between Wisconsin Card Sorting Test (WCST) scores and the results of tasks in which PD patients displayed deficits (SRT and pairs of Japanese ideograms) were discovered. Interestingly, such a correlation was found in the case of MR and words pairs tasks, which did not distinguish PD patients from control group.
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