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1
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Review on analgesic effect of co-administrated ibuprofen and caffeine

100%
Polski A., Kasperek R., Sobotka-Polska K., Poleszak E.
Current Issues in Pharmacy and Medical Sciences
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2014
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vol. 27
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issue 1
10-13
EN
Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as analgesics. Other, easier way is to combine already known drugs which cause synergistic effects greater than additive, so that probability of drug-specific side effects can be reduced. Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans. By using modern drug technology methods tablets containing well-soluble ibuprofen salt and caffeine can be easily prepared. Thanks to that combination, the therapeutic dose of ibuprofen can be lowered and the side effects may be reduced.
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A brief analysis of patients suffering from stomach or duodenal ulcers in Almaty hospital №1

88%
Aryzbekova A., Juszkiewicz K. T., Burgess D. E., Polski A., Poleszak E.
Current Issues in Pharmacy and Medical Sciences
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2015
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vol. 28
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issue 4
241-243
EN
Peptic ulcers are a serious problem worldwide, and affect about 4 million people each year. Their etiology is connected with the presence of Helicobacter pylori, the act of smoking, drinking alcohol, being stress, and taking excessively nonsteroidal anti-inflammatory drugs, as well as steroids. The most common symptoms are abdominal pain, nausea, chest pain and fatigue, while less frequent symptoms include vomiting and weight loss. Helicobacter pylori is responsible for about 80% of gastric and 90% of duodenal ulcer cases. In this work, an analysis is made of a correlation between stomach or duodenal ulcer and gender, residence and number of patients hospitalized in the Almaty hospital №1, from 2009-2012, in order to learn about trends in the incidence of these diseases in Kazakhstan. A total number of 950 patients with stomach and duodenal ulcers, in 2009-2012, were questioned. The patient’s residence, gender and stomach or duodenal ulcer problem were taken into account in the study. The result of this work reveals that the largest amount of hospitalized patients suffering from stomach or duodenal ulcers came from urban areas. Moreover, more women than men suffered from peptic ulcers. Furthermore, the number of patients admitted to the hospital due to duodenal ulcers did not show any variation throughout the study. However, the least number of patients suffering from gastric ulcers was noticed in December 2009, and the greatest was in October and November 2011. The obtained data show that ulcers are a serious problem in Kazakhstan.
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Influence of the dissolution medium on the release of dehydroepiandrosterone from lipophilic suppositories

88%
Kasperek1 R., Galczynski K., Nalesniak M., Iwaniak K., Poleszak E.
Current Issues in Pharmacy and Medical Sciences
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2014
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vol. 27
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issue 1
46-50
EN
Suppositories with cocoa butter containing dehydroepiandrosterone (DHEA) without and with the addition of Span 80 and Tween 80 as surfactants with low and high HLB values were prepared. The physical properties and the drug content of all prepared suppositories were in accordance with the pharmacopoeial requirements. The release study tests in three dissolution media such as water, lactic acid solution at pH 4.2 and phosphate buffer at pH 7.4 were carried out. In acidic and alkalic media only about 10% and 27% of DHEA were released, respectively. The addition of Span 80 to the suppository mass did not improve the release process, but the addition of Tween 80 caused the increase in the amount of DHEA released in the acidic medium to about 35%. The data showed that rectal administration of suppositories with DHEA based on cocoa butter caused about 30% availability and after vaginal administration, only topical activity can be expected. By the addition of Tween 80 to the suppository mass availability of DHEA of about 35% from vaginal suppositories can be achieved.
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Kinetics of the decomposition and the estimation of the stability of 10% aqueous and non-aqueous hydrogen peroxide solutions

76%
Zun M., Dwornicka D., Wojciechowska K., Swiader K., Kasperek R., Rzadkowska M., Poleszak E.
Current Issues in Pharmacy and Medical Sciences
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2014
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vol. 27
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issue 4
213-216
EN
In this study, the stability of 10% hydrogen peroxide aqueous and non-aqueous solutions with the addition of 6% (w/w) of urea was evaluated. The solutions were stored at 20°C, 30°C and 40°C, and the decomposition of hydrogen peroxide proceeded according to first-order kinetics. With the addition of the urea in the solutions, the decomposition rate constant increased and the activation energy decreased. The temperature of storage also affected the decomposition of substance, however, 10% hydrogen peroxide solutions prepared in PEG-300, and stabilized with the addition of 6% (w/w) of urea had the best constancy.
5
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A botanical and pharmacological description of petasites species

76%
Tys J., Szopa A., Lalak J., Chmielewska M., Serefko A., Poleszak E.
Current Issues in Pharmacy and Medical Sciences
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2015
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vol. 28
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issue 3
151-154
EN
The objective of this review was to evaluate the botanical and pharmacological description of Petasites species. Petasides (butterbur) as a perennial shrub which was found in Europe and also in a parts of Asia and North America, has been widely used medicinally for centuries. At present, the main phytopharmacology uses for Petasides extracts are for prophylactic treatment of migraines, as well as an antispasmodic agent for bronchial asthma and pertussis. Furthermore, it has been used effectively in preventing gastric ulcers, and in urinary tract spasms and treating patients with irritable bladder. But still, there is a need for more studies on the potential applications of butterbur extract in medicine.
6
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Physical properties and caffeine release from creams prepared with different oils

76%
Wojciechowska K., Zun M., Dwornicka D., Swiader K., Kasperek R., Poleszak E.
Current Issues in Pharmacy and Medical Sciences
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2014
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vol. 27
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issue 4
224-228
EN
Caffeine is a methylxanthine typically found in the Coffee Arabica L plant. Generally, caffeine is well-known as a orally administered mild stimulant of the central nervous system. However, for cosmetic purpose, caffeine is an active compound ingredient, at 7% concentration, in several anticellulite products. The efficiency of this mode of delivery is not fully understood. Hence, the aim of the study was to ascertain the effectiveness of particular carriers to release this ingredient. In so doing, we prepared six creams based upon different oils (Sesame oil, Rice oil, Walnut oil, Coconut oil, Sweet almond oil and Jojoba oil), containing 5% of caffeine, and compared the release of the substance from the obtained preparations. Initially, all of the creams were subjected to a variety of physical tests, among these being for slippage and spreadability. Furthermore, their rheological properties were evaluated. Subsequently, the creams were tested for caffeine release. In the slippage and spreadability tests, the coconut oil-based cream was revealed as having the best parameters. However, the rheological tests showed that all of the preparations had the pseudoplastic character of flowing according to the Ostwald de Waele power law model. The power low index (n) for all the preparations was from 0.2467-0.3179 at 20°C and 0.2821-0.3754 at 32°C. At 20°C, the Sesame oil-, Walnut oil-, Sweet almond oil- and Jojoba oil-based creams were thixotropic, but at 32°C, thixotropy appeared only in the Walnut oil-based creams. The release studies, conducted by way of an extracting chamber (according to Polish Pharmacoeia IX) in the Paddle Apparatus (according to Polish Pharamcopoeia IX), showed that the amount of released caffeine is the largest in the case of Jojoba oil-based cream, at 85.23% ± 0.8% (SD), and the least in the case of Coconut oil-based cream, at 62,78%± 0.87% (SD).
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The inflluence of emulsifiers on physical properties and release parameters of creams with caffeine

76%
Dwornicka D., Wojciechowska K., Zun M., Kasperek R., Swiader K., Szumilo M., Poleszak E.
Current Issues in Pharmacy and Medical Sciences
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2015
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vol. 28
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issue 2
81-84
EN
Caffeine is well known alkaloid chemical compound belonging to the methyl-xanthines group. It is an active substance that is found in many cosmetic products, as it has a stimulating action on both the central nervous system and the metabolism. Commercially available topical formulations normally contain 3% of caffeine and 7% anticellulite products. The aim of our work was to investigate the properties of four cream preparations. These consisted of 5% of caffeine and one of four different emulsifiers (GSC, Sodium polyacrylate, Emulsifying Base, MDS). In our work, we compared the physical properties (spreadability, slip and tenacity), the rheological structure of the resulting creams and the caffeine release from the obtained preparations. The results showed that the properties of these creams and their drug release depended upon the kind of the emulsifiers utilised. What is more, all preparations have a pseudoplastic character of flow and most of them have significant thixotropy. Furthermore, the amount of released caffeine is the largest from the MDS cream, and this emulsifier seems to be the most optimal in all the examined items.
8
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RELEASE OF BIOACTIVE SUBSTANCES FROM FORMULATIONS CONTAINING ARTHROSPIRA PLATENSIS (SPIRULINA PLATENSIS)

64%
Muszyńska B., Lazur J., Jękot B., Krakowska A., Szewczyk A., Sułkowska-Ziaja K., Zimmer Ł., Poleszak E., Opoka W.
Acta Poloniae Pharmaceutica - Drug Research
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2018
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vol. 75
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issue 5
1187-1199
EN
Arthrospira platensis (Spirulina platensis) is a well-known microalga and has been utilized as a medicinal agent and foodstuff by humans since at least 16th century. The aim of this study was to determine zinc content as well as determine phenolic and indole compounds from commercial preparations containing Arthrospira platensis (lyophilizate, tablets, and capsules) before and after extraction with methanol and incubation with artificial digestive juices. The secondary aim of this study was to evaluate the quality of these preparations. The samples were incubated in artificial stomach juice and in intestinal juice. The samples were mineralized and their zinc(II) ions content was estimated using flame absorption atomic spectroscopy (F-AAS). The maximum zinc(II) ions content released into the digestive juices was found to be up to 1.6 mg 100 g-1 of the preparation. Phenolic compounds identified in the examined extracts are as follows: gallic acid; protocatechuic acid; 3,4-dihydroxyphenylacetic acid; p-hydroxybenzoic acid; syringe acid; cinnamic acid; and quercetin. Furthermore, indole compounds identified were 5-hydroxy-L-tryptophan, 5-methyl-L-tryptophan, L-tryptophan, tryptamine, and 5-methyltryptamine. Consequently, it was also found that the distributed Arthrospira platensis in the form of tablets does not disintegrate in the artificial digestive juices. Among the examined preparations, only hard capsules met the requirements of the European Pharmacopeia 8th ed.
9
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The effect of a combined choline salicylate and cetalkonium chloride gel on particular strains of Pseudomonas aeruginosa, Staphylococcus spp. and Streptococcus spp.

64%
Amangeldykyzy S., Nurlybek A. N., Nurlan A. N., Juszkiewicz K. T., Polski A., Seisembay U. B., Mukasheva A. M., Umirzakovna U. K., Poleszak E.
Current Issues in Pharmacy and Medical Sciences
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2015
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vol. 28
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issue 2
77-80
EN
The ongoing control of virulent bacteria strains is a challenge for today’s medicine. An example of this, is one widely used drug employed in treating less serious external oral and ocular bacterial infections. This is a gel containing both cetalkonium chloride and choline salicylate. However, whether in the era of expanding bacterial resistance this gel is still effective, is not clear. Hence, in our work, its antibacterial effect was studied against 13 strains of Pseudomonas aeruginosa, 6 strains of Staphylococcus spp. and 6 strains of Streptococcus spp. drawn from the collection of the Department of Microbiology, Virology and Immunology, Kazakh National Medical University, as well as against 30 strains of Staphylococcus spp. recently isolated from Kazakh medical students. This work demonstrated that Pseudomonas aeruginosa was insensitive to this preparation in all samples, while the sensitivity of Staphylococcus spp. and Streptococcus spp. was almost halved, compared to untreated samples. An interesting discovery was the greater resistance of strains obtained from student volunteers than from the collection. However, despite the evident resistance of some strains to the combined cetalkonium chloride and choline salicylate gel, we put forward that it can still be used in less serious external bacterial infections.
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