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Autoimmune hepatitis after high-dose intravenous methylprednisolone pulse in RR-MS

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Reuß R., Retzlaff K., Vogel S., Franke F., Oschmann P.
Open Medicine
|
2007
|
vol. 2
|
issue 3
356-359
EN
Three weeks after the administration of intravenous methylprednisolone therapy, a 42-year-old female patient suffering from relapsing-remitting multiple sclerosis (RR-MS) presented with a profound elevation of liver transaminases (GOT 485 U/l, GPT 1082 U/l, glutamyl transpeptidase 170 U/l). Liver biopsy revealed a profound, still active hepatitis with portal lymphocytic infiltration and fibrosis. Most likely, existing acute hepatitis was of autoimmune origin and emerged from an immune rebound phenomenon after immunosuppressive therapy.
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