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The role of dendritic cells in neurodegenerative diseases

100%

Iribarren P., Cui Y.-H., Le Y., Wang J. M.

Archivum Immunologiae et Therapiae Experimentalis

2002

vol. 50

issue 3

187-196

Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) involved in the induction of adaptive immune responses. The presence of DCs in the central nervous system (CNS) and the active participation of the immune system in a variety of neurodegenerative diseases have been demonstrated. This review will discuss recent findings pertinent to DCs and other antigen presenting cells in CNS in health and disease states.

A burgeoning family of biological mediators: chemokines and chemokine receptors

76%

Le Y., Gong W., Shen W., Li B., Dunlop N. M., Wang J. M.

vol. 48

issue 3

143-150

Chemokines are a superfamily of pro-inflammatory polypeptide cytokines that selectively attract and activate different cell types. Most of its members are small proteins that exhibit conserved cysteines in specific positions. Chemokines activate cells through their binding to shared or unique cell surface receptors which belong to the seven-transmembrane (STM), G-protein-coupled receptors (GPCRs). The large number of chemokines and chemokine receptors are indicative of the importance of these molecules in a variety of pathophysiological conditions.

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2 Archivum Immunologiae et Therapiae Experimentalis

1 2002

1 2000

2 Le Y.

2 Wang J. M.

1 Cui Y.-H.

1 Dunlop N. M.

1 Gong W.

1 Iribarren P.

1 Li B.

1 Shen W.

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The role of dendritic cells in neurodegenerative diseases

A burgeoning family of biological mediators: chemokines and chemokine receptors