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1

Biodegradation of oil-derived compounds by filamentous fungi

100%

Lisowska K., Dlugonski J.

Biotechnologia

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2003

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issue 4

92-100

EN

The development of industry, especially oil and chemical branches, resulted in the contamination of the natural environment by oil-derived compounds, including polycyclic aromatic hydrocarbons (PAHs). These compounds are highly toxic to the living organisms, most of them expressing carcinogenic properties. Microbiological degradation is one of the main methods of removing PAHs from the environment. Biodegradation reduces the costs of recultivation by considerable acceleration of the degradation of those compounds in the soil. Microscopic fungi play an important role in the process of PAHs detoxification and degradation. Our studies have shown that a number of strains involved in the steroids transformation are also capable of PAHs degradation. Due to the fact that both processes involve the participation of cytochrome P-450, these strains are convenient research models for explaining the dependence between steroid hydroxylases and enzymes responsible for PAHs degradation. The currently performed research is aimed at developing the possibilities of employing microorganisms used for the production of steroid drugs in the protection of the environment.

2

Viral strategies in modulation of NF-kappaB activity

100%

Lisowska K., Witkowski J. M.

Archivum Immunologiae et Therapiae Experimentalis

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2003

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vol. 51

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issue 6

367-375

EN

Activation of nuclear factor (NF)-kappaB transcription factors family in response to different stimuli such as inflammatory cytokines, stress inducers or pathogens? products results in host innate and adaptive immunity. NF-kappaB plays a central role in promoting the expression of genes involved in inflammatory, immune and apoptotic processes, including those encoding cytokines, chemokines, cytokine receptors or proteins involved in antigen presentation. Although the main function of NF-kappaB is to activate specific genes in the cells of the immune system, its role in controlling the host cell cycle makes NF-kappaB an interesting target for pathogenic viruses. Some viruses take advantage of anti-apoptotic properties of NF-kappaB to escape host defence mechanisms, other use apoptosis to spread. This review describes the role of NF-kappaB family in immune responses, mechanism of NF-kappaB activation and different strategies that viruses have developed to modulate NF-kappaB pathway in order to facilitate and enhance viral replication and avoid host immune responses.

3

Biodegradation and detoxification of xenobiotics and compounds of natural origin

71%

Dlugonski J., Lisowska K., Paraszkiewicz K., Slaba M., Bernat P.

Biotechnologia

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2003

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issue 4

62-68

EN

Microscopic fungi are widely used for synthesis and transformation of biologically active compounds e.g. antibiotics, corticosteroids and androgens. The fungal strains applied for steroid hormone production are also able to attack pollutants, including deleterious xenobiotics e.g. polycyclic aromatic hydrocarbons (PAHs), chlorophenols or organotins to less toxic derivatives. Transformation, detoxification, and degradation of both types of hydrophobic substrates (steroids and xenobiotics), as well as heavy metals recovery from industrial wastes, are in the center of interest of Department of Industrial Microbiology and Biotechnology. This paper is a short review on a possibility of application of industrial strains for environment protection and an introduction to our detailed presentations (1-4) on this subject, during The 2nd National Biotechnology Congress in Lodz.

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2 Biotechnologia

1 Archivum Immunologiae et Therapiae Experimentalis

3 2003

3 Lisowska K.

2 Dlugonski J.

1 Bernat P.

1 Paraszkiewicz K.

1 Slaba M.

1 Witkowski J. M.

Biodegradation of oil-derived compounds by filamentous fungi

Viral strategies in modulation of NF-kappaB activity

Biodegradation and detoxification of xenobiotics and compounds of natural origin