Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 5

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Content available remote

Thiamine prevents X-ray induction of genetic changes in human lymphocytes in vitro.

100%
Konopacka M., Rogoliński J.
|
|
vol. 51
|
issue 3
839-843
EN
The effects of thiamine (vitamin B1) on the level of spontaneous or radiation-induced genetic changes in human lymphocytes in vitro were studied. Cultured lymphocytes were exposed to increasing concentrations of thiamine (0-500 μg/ml) and irradiated with X-rays. The DNA damage was estimated as the frequency of micronuclei and apoptotic or necrotic morphological changes in fixed cells. The results show that thiamine alone did not induce genetic changes. A significant decrease in the fraction of apoptotic and necrotic cells was observed in lymphocytes irradiated in the presence of vitamin B1 at concentrations between 1-100 μg/ml compared to those irradiated in the absence of thiamine. Vitamin B1 at 1 and 10 μg/ml decreased also the extent of radiation-induced formation of micronuclei. Vitamin B1 had no effect on radiation-induced cytotoxicity as measured by nuclear division index. The results indicate that vitamin B1 protects human cells from radiation-induced genetic changes.
2
Content available remote

Interactions of the matrix attachment region of DNA with the matrix proteins from the copper preincubated liver nuclei

81%
Widłak P., Rogoliński J., Rzeszowska-Wolny J.
|
3
Content available remote

Interactions of rat repetitive sequence MspI8 with nuclear matrix proteins during spermatogenesis

80%
Rogoliński J., Widłak P., Rzeszowska-Wolny J.
Acta Biochimica Polonica
|
1996
|
vol. 43
|
issue 2
319-324
4
Content available remote

MspI8, the repetitive sequence specifically interacting with nuclear matrix of rat testis cells

80%
Rzeszowska-Wolny J., Rogoliński J.
Acta Biochimica Polonica
|
1994
|
vol. 41
|
issue 4
459-466
5
Content available remote

VDR gene single nucleotide polymorphisms and their association with risk of oral cavity carcinoma

42%
Małodobra-Mazur M., Paduch A., Lebioda A., Konopacka M., Rogoliński J., Szymczyk C., Wierzgoń J., Maciejewski A., Chmielik E., Jonkisz A., Półtorak S., Dobosz T.
|
2012
|
vol. 59
|
issue 4
627-630
EN
Vitamin D3 (1,25(OH)2D3 (1,25-dihydroxyvitamin D3)) is a hormone playing a crucial role in numerous biological processes in the human body, including induction and control of cell proliferation and differentiation. Numerous data relate the vitamin D3 level with various types of cancer. It has been suggested that SNPs in the vitamin D3 receptor (VDR) gene might influence both the risk of cancer occurrence and cancer progression. The aim of this study was to search for genetic correlations between individual SNPs in the VDR gene and the risk of oral cavity carcinoma. Two SNPs were selected based on the literature and our previous results. Seventy-three patients with squamous cell carcinoma of the head and neck and one hundred control subjects were investigated. Two SNPs in the VDR gene were genotyped in minisequencing reactions followed by capillary electrophoresis. Hardy-Weinberg equilibrium (HWE), the χ2 test and logistic regression were used for statistical analysis. The SNP rs2238135 in the VDR gene displayed statistical differences in frequency between the tested groups (p=0,0007). Furthermore, the G/C genotype of the rs2238135 in the VDR gene was characterized by a 3.16 fold increased risk of oral cavity carcinoma. The obtained results provide evidence for a genetic association between rs2238135 in the VDR gene and the occurrence and risk of oral cavity cancer.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.