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Consumption and awareness of students about nonsteroidal anti-inflammatory drugs

100%
Wawryk-Gawda E., Chylinska-Wrzos P., Lis-Sochocka M., Jodlowska-Jedrych B.
Current Issues in Pharmacy and Medical Sciences
|
2014
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vol. 27
|
issue 3
175-178
EN
Nonsteroidal anti-inflammatory drugs (NSAIDs) are used by millions of people worldwide to neutralize pain that is of different origin, as well as to treat fever and inflammation. However, NSAIDs misuse/overuse can induce many adverse effects and some potentially serious complications. The aim of the our study was to ascertain young people’s knowledge about non-steroidal anti-inflammatory drugs. The research tool was a questionnaire. This study was carried out among students of the Medical University in Lublin, and it involved 236 persons of an average age of 20 years. The questions were intended to assess the frequency of NSAIDs use and the general knowledge that is held with respect to them. The results of this work show that more than 77% of the respondents confirmed that they use NSAIDs. Our results revealed no statistical correlation between the place of living or origin and the use of this drug. Hence, it can be said that while young adults quite often use NSAIDs, their knowledge about the dangers associated with the use of NSAIDs is low. Therefore, it is necessary to more intensively disseminate knowledge on the potential adverse effects of NSAID utilization.
2
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Back pain and physical activity: Students of the Medical University of Lublin

88%
Lis-Sochocka M., Chylinska-Wrzos P., Wawryk-Gawda E., Bulak K., Jodlowska-Jedrych B.
Current Issues in Pharmacy and Medical Sciences
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2015
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vol. 28
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issue 4
278-282
EN
At the present time, back pain and posture problems affect a growing number of young people. This is probably due to a changing lifestyle which has led to less physical activity. The aims of our study were to evaluate the prevalence of pain associated with the spine, as well as to ascertain the relationship of these symptoms with the degree of physical activity among a group of students of the Medical University of Lublin. The research group consisted of 301 students (201 women and 100 men) aged between 19 and 27 years. The survey was performed at the turn of the year 2014/2015. Based on an anonymous questionnaires, we found that treatment and advice obtained at the faulty posture and/or orthopedic clinic benefited slightly more than 32% of all respondents. In this group, about 20% were women, while among men, it was a little over 12%. Physical therapy to treat back problems was also entered into by about 29% of the respondents, while 5% of students undertook such treatment very frequently. What is more, 89% of all respondents stated they regularly attend physical education classes. Moreover, more than 81% of all students surveyed practiced some sport, in this group - about 51% of the respondents stating so were women, and a little over 29% were men. Although medical students are a group of people with high health issue awareness, they are not deprived of problems related to the musculoskeletal system.
3
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Do you know what you eat? Students of the Medical University of Lublin and food consumption awareness

88%
Chylinska-Wrzos P., Lis-Sochocka M., Wawryk-Gawda E., Bulak K., Jodlowska-Jedrych B.
Current Issues in Pharmacy and Medical Sciences
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2015
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vol. 28
|
issue 4
260-263
EN
At the present time, consumers are paying more attention to the food items they purchase, and, hence, organic products, more and more, are a popular choice. Furthermore, there is an increased awareness of the ingredients added as fixatives and taste modifiers. Medical students are assumed to have greater health awareness, and to recognize that proper nutrition has a significant impact on the overall physical well-being. Moreover, they are thought to be aware of the chemical composition of consumed foods. The aim of our study was to truly assess the degree of consumer awareness amongst students of the Medical University of Lublin. The research study consisted of 301 students of the I and II years, the work being performed at the turn of the year 2014/2015. The research tool was an anonymous questionnaire. This contained questions regarding their degree of healthy food awareness of retailed food products. The results of this study revealed that about 44% of the respondents always or often pay attention to the composition of the food products which they buy. Indeed, the highest percentage of all respondents declared that their purchase of food products is guided by the declared (labeled) composition (48.84% of the students coming from urban settings, and 55.81% coming from rural districts). Of note, regarding products labeled organic, from both urban and rural origin, such items were chosen by approximately 50% of the respondents. Finally, only a small percentage of students (about 9% overall) stated that they avoid foods stated to contain preservatives. In summary, despite the increasing availability of healthy foods, such items are not too often chosen by UM students - Indeed, despite the large biomedical knowledge purportedly held, medical students, in particular, do not avoid foods containing preservatives.
4
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The effect of one-electron reduced drugs on hepatic aconitase activity and triglycerides level

64%
Wnukowska M., Mandziuk S., Korga A., Jodlowska-Jedrych B., Matysiak W., Halasa J., Burdan F., Iwan M., Gieroba R., Dudka J.
Current Issues in Pharmacy and Medical Sciences
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2015
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vol. 28
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issue 1
5-7
EN
The redox cycle triggered by one electron reduction of doxorubicin and tirapazamine - both anticancer agents - leads to superoxide production. This superoxide production itself removes one iron atom from the [4Fe-4S] cluster, being an active center of aconitase. In addition, the incurred changes in cell redox equilibrium may affect lipid metabolism. The aim of the study was to evaluate a concomitant effect of both drugs on hepatic aconitase activity and triglycerides level. In our study, doxorubicin (1.8 mg/kg b.w.) was administered intraperitoneal (i.p.) six times, once a week, within male Wistar rats, to achieve a cumulative dose of 10.8 mg/kg b.w. Two hours before every doxorubicin administration, tirapazamine in the dose of either 5 or 10 mg/kg b.w. was also i.p. injected. A week after withdrawing drug administration, the liver was taken for biochemical analysis. Therein, an increase in aconitase activity and a decrease in triglycerides level was seen in all groups exposed to doxorubicin. Our work demonstrated that tirapazamine administration had no influence on both tested parameters, but its higher dose rate normalized aconitase activity affected by doxorubicin.
5
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The effect of thyroxin on hepatic redox equilibrium and lipid metabolism in rats treated with doxorubicin

52%
Czuba B., Fituch M., Mandziuk S., Jodlowska-Jedrych B., Matysiak W., Halasa J., Burdan F., Korga A., Iwan M., Luszczewska-Sierakowska I., Dudka J.
Current Issues in Pharmacy and Medical Sciences
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2014
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vol. 27
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issue 4
220-223
EN
The main side effects of the administration of doxorubicin, a widely used anticancer drug, is the generation of a reactive oxygen species (ROS) in normal cells. As a result, redox disorders and secondary oxidative stress are developed. Doxorubicin ROS generation is attributed to enzymes that are produced abundantly in hepatocytes. Oxidative stress has been a well-known risk factor of doxorubicin-related toxicity. However, in addition, according to the data collected in the last decade, changes in thyroxin status can propagate ROS generation, and, thus, initiate the doxorubicin hepatic effect. Moreover, both compounds have an impact on the cell metabolism. The aim of the study was to verify the thesis that thyroxin can modulate the effect of doxorubicin with regard to redox status and lipid metabolism disorders. In our work, we determined the ratio of NADP+/ NADPH and NAD+/NADH in liver homogenates, blood ketone bodies and triglycerides in the liver and blood in rats treated with doxorubicin and thyroxin. Our results indicate that thyroxin has an insignificant effect on NAD+/NADH, NADP+/NADPH ratios and on hepatic and blood triglycerides. Moreover, thyroxin administration normalized the level of blood ketone bodies that was disturbed by doxorubicin.
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