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EFFECTS OF VITAMIN D3 AND RESVERATROL ON MEMORY AND LEARNING IMPAIRMENT IN MICE WITH STREPTOZOTOCIN INDUCED DIABETES

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Kukula O.

Acta Poloniae Pharmaceutica - Drug Research

2019

vol. 76

issue 3

563-568

This study was conducted for investigating the effects of chronically administered vitamin D3 and resveratrol, which has antioxidant properties, on memory and learning impairment caused by streptozotocin-induced diabetes. Saline was administered to the mice in the first group. Streptozotocin (60 mg/kg, i.p.) was given to the mice in the second group for 3 consecutive days and no treatment was performed. Vitamin D3 (800 IU/kg, i.p.) was given to the streptozotocin-induced hyperglycemic mice in the third group for 4 weeks. Resveratrol (40 mg/kg, i.p.) was given to the streptozotocin-induced hyperglycemic mice in the fourth group for 4 weeks. Then, passive avoidance test was applied to the mice. A significant difference was found between DM+Vit D3 group (21.6±1.7, n=7) and diabetic control group (28±2.6, n=7) in the acquisition test (p<0.001). A similar result was observed between diabetic-resveratrol group (23.7±2.5, n=7) and the untreated diabetic mice group (28±2.6, n=7). There was a significant difference. 4-week vitamin D3 (400 IU/day, i.p.) and 4-week resveratrol (40 mg/kg, i.p.) treatments given to streptozotocin-induced diabetic mice were observed to significantly improved the passive avoidance acquisition and retention times. These results show the positive effects of vitamin D3 on memory.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 2019

1 Kukula O.

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EFFECTS OF VITAMIN D3 AND RESVERATROL ON MEMORY AND LEARNING IMPAIRMENT IN MICE WITH STREPTOZOTOCIN INDUCED DIABETES